SCHEMBL14020366

SCHEMBL14020366

CSc1nc(N)nc(Cl)n1

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HSP90AB1 P08238 2/20 0.58
HSP90AA1 P07900 10/20 0.49
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
ABCB1 P08183 1/20 0.32
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32
ALDH1A1 P00352 1/20 0.32
ALOX15 P16050 1/20 0.32
TSHR P16473 1/20 0.32
PDE4A P27815 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL383476 0.82 ALDH1A1 (0.41) HSP90AB1HSP90AA1MEN1KMT2ANPC1
SCHEMBL6765323 0.82 ALDH1A1 (0.50) HSP90AB1HSP90AA1MEN1KMT2ANPC1
SCHEMBL8071682 0.82 HSP90AB1 (0.71) HSP90AB1HSP90AA1ABCB1ADORA2AADORA1
SCHEMBL3631158 0.82 HSP90AB1 (0.71) HSP90AB1HSP90AA1ABCB1ADORA2AADORA1
SCHEMBL164162 0.73 HSP90AB1 (0.54) HSP90AB1HSP90AA1KMT2ANPC1RAB9A
SCHEMBL10876554 0.73 HSP90AB1 (1.00) HSP90AB1HSP90AA1MEN1KMT2ANPC1
SCHEMBL197055 0.73
SCHEMBL79810 0.73
SCHEMBL9350626 0.71 HSP90AB1 (0.52) HSP90AB1HSP90AA1ABCB1ADORA2AADORA1
SCHEMBL1061788 0.70 HSP90AB1 (0.44) HSP90AB1HSP90AA1MEN1KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7439340-B2 For exhaust dyeing, cold batch-up dyeing and continuous dyeing EVERLIGHT USA, INC. (US) 2008-10-21 US disclosed
US-20080207881-A1 Reactive dyes containing an alkylthio-s-triazinyl reactive group EVERLIGHT USA, INC. (US) 2008-08-28 US disclosed
US-20080039614-A1 Reactive dyes containing an alkylthio-s-triazinyl reactive group EVERLIGHT USA, INC. (US) 2008-02-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080207881-A1 Reactive dyes containing an alkylthio-s-triazinyl reactive group TST, IK, NOX5 HSP90AB1 1569/4885HSP90AA1 1956/4885MEN1 4709/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.