Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 12/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13004938 | 0.90 | KIF11 (0.52) | KIF11GAAARSLC6A2SLC6A4 | |
| SCHEMBL14020845 | 0.75 | KIF11 (0.51) | KIF11ARKDM4ELMNAHTT | |
| SCHEMBL12751149 | 0.73 | KIF11 (0.69) | KIF11GAA | |
| SCHEMBL10101303 | 0.73 | KIF11 (0.69) | KIF11GAAAR | |
| SCHEMBL14019804 | 0.73 | KIF11 (0.46) | KIF11GAAARKDM4EMEN1 | |
| SCHEMBL12751147 | 0.73 | KIF11 (0.69) | KIF11GAA | |
| SCHEMBL13831889 | 0.73 | KIF11 (0.40) | KIF11GAAARKDM4ELMNA | |
| SCHEMBL10102694 | 0.72 | KIF11 (0.87) | KIF11GAA | |
| SCHEMBL10101416 | 0.72 | AR (0.67) | KIF11GAAARKDM4EMEN1 | |
| SCHEMBL23949460 | 0.71 | HNF4A (0.39) | GAAARKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761515-B1 | 2-(HETERO-)ARYL SUBSTITUTED TETRAHYDROQUINOLINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2008-11-05 | — | — | EP | disclosed |
| US-20070203167-A1 | 2-(Hetero)-aryl substituted tetrahydrochinoline | MERCK PATENT GMBH (DE) | 2007-08-30 | — | — | US | disclosed |
| US-20070203167-A1 | 2-(Hetero)-aryl substituted tetrahydrochinoline | MERCK PATENT GMBH (DE) | 2007-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203167-A1 | 2-(Hetero)-aryl substituted tetrahydrochinoline | NCOR1, CCNT2, NCOR2 | KIF11 4054/4885GAA 4282/4885AR 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.