Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.54 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.54 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.54 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14022269 | 0.80 | PRMT5 (0.69) | PI4KAPI4K2BPI4K2API4KBGSK3B | |
| SCHEMBL28700989 | 0.80 | PI4KA (0.62) | PI4KAPI4K2BPI4K2API4KBGSK3B | |
| SCHEMBL14022279 | 0.75 | MAPK13 (0.42) | PI4KAPI4K2BPI4K2API4KBGSK3B | |
| SCHEMBL14022274 | 0.74 | GSK3B (0.52) | PI4KAPI4K2BPI4K2API4KBGSK3B | |
| SCHEMBL28267366 | 0.72 | NPC1 (0.55) | PI4KAPI4K2BPI4K2API4KBGSK3B | |
| SCHEMBL4046146 | 0.72 | METAP2 (0.64) | PI4KAPI4K2BPI4K2API4KBGSK3B | |
| SCHEMBL1284270 | 0.70 | AURKA (0.73) | PRMT5AURKA | |
| SCHEMBL9175738 | 0.70 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBGSK3B | |
| SCHEMBL783654 | 0.70 | PI4KA (0.67) | PI4KAPI4K2BPI4K2API4KBGSK3B | |
| SCHEMBL9731613 | 0.70 | PI4KA (0.67) | PI4KAPI4K2BPI4K2API4KBGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080255106-A1 | Novel 2-Phenyl-Imidazo[4,5-B]Pyridine Derivatives as Inhibitors of Glycogen Synthase Kinase for the Treatment of Dementia and Neurodegenerative Disorders | ASTRAZENECA AB (SE) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255106-A1 | Novel 2-Phenyl-Imidazo[4,5-B]Pyridine Derivatives as Inhibitors of Glycogen Synthase Kinase for the Treatment of Dementia and Neurodegenerative Disorders | GSK3B, PYGB, GSK3A | PI4KA 172/4885PI4K2B 151/4885PI4K2A 213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.