Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.62 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.62 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.62 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.53 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14022269 | 0.80 | PRMT5 (0.69) | PI4KAPI4K2BPI4K2API4KBFGFR1 | |
| SCHEMBL14022271 | 0.80 | PI4KA (0.54) | PI4KAPI4K2BPI4K2API4KBFGFR1 | |
| SCHEMBL9175738 | 0.77 | PI4KA (1.00) | PI4KAPI4K2BPI4K2API4KBFGFR1 | |
| SCHEMBL14022274 | 0.74 | GSK3B (0.52) | PI4KAPI4K2BPI4K2API4KBFGFR1 | |
| SCHEMBL3693391 | 0.73 | PI4KA (0.46) | PI4KAPI4K2BPI4K2API4KBGSK3B | |
| SCHEMBL3696208 | 0.73 | PI4KA (0.58) | PI4KAPI4K2BPI4K2API4KBFGFR1 | |
| SCHEMBL1895948 | 0.72 | NPC1 (0.55) | PI4KAPI4K2BPI4K2API4KBFGFR1 | |
| SCHEMBL4046146 | 0.72 | METAP2 (0.64) | PI4KAPI4K2BPI4K2API4KBFGFR1 | |
| SCHEMBL1284270 | 0.70 | AURKA (0.73) | PRMT5AURKA | |
| SCHEMBL783654 | 0.70 | PI4KA (0.67) | PI4KAPI4K2BPI4K2API4KBFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109563092-B | 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 | 坎塞拉有限公司 | 2021-09-14 | — | — | CN | disclosed |
| CN-109563092-B | 2-phenylimidazo [4,5-B ] pyridin-7-amine derivatives useful as inhibitors of the activity of the mammalian tyrosine kinase ROR1 | 坎塞拉有限公司 | 2021-09-14 | — | — | CN | disclosed |