Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4789418 | 0.89 | HTT (0.49) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL5007660 | 0.85 | MEN1 (0.48) | MAPTHTTRAB9AKDM4E | |
| SCHEMBL303719 | 0.80 | TDP1 (0.45) | TDP1MAPTL3MBTL1ALDH1A1LMNA | |
| SCHEMBL5011669 | 0.76 | KDM4E (0.59) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL1774427 | 0.76 | TDP1 (0.44) | TDP1MAPTL3MBTL1ALDH1A1LMNA | |
| SCHEMBL5009194 | 0.74 | MEN1 (0.44) | MAPTRAB9AADORA2A | |
| SCHEMBL6167298 | 0.74 | ALDH1A1 (0.58) | TDP1ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL14037083 | 0.74 | NPC1 (0.67) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL4789419 | 0.73 | HTT (0.49) | MAPTALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL4886620 | 0.72 | JMJD6 (0.43) | TDP1MAPTL3MBTL1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008135578-A1 | PYRAZOLO [3, 4-D] PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION AND/OR ALLERGIC CONDITIONS | GLAXO GROUP LIMITED (GB) | 2008-11-13 | — | — | WO | disclosed |