Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.43 |
| ▸ | USP7 | Q93009 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6167298 | 0.75 | ALDH1A1 (0.58) | RAB9ATDP1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL303719 | 0.73 | TDP1 (0.45) | JMJD6RAB9ATDP1MAPTL3MBTL1 | |
| SCHEMBL14022280 | 0.72 | TDP1 (0.44) | JMJD6RAB9ATDP1MAPTL3MBTL1 | |
| SCHEMBL1774427 | 0.69 | TDP1 (0.44) | JMJD6RAB9ATDP1MAPTL3MBTL1 | |
| SCHEMBL6165847 | 0.67 | RAB9A (0.50) | JMJD6RAB9ATDP1MAPTL3MBTL1 | |
| SCHEMBL312910 | 0.67 | TDP1 (0.81) | JMJD6RAB9ATDP1MAPTKMT2A | |
| SCHEMBL19527664 | 0.66 | SMN1; SMN2 (0.52) | JMJD6RAB9ATDP1MAPTL3MBTL1 | |
| SCHEMBL19527579 | 0.66 | SMN1; SMN2 (0.49) | JMJD6RAB9ATDP1MAPTL3MBTL1 | |
| SCHEMBL8761237 | 0.66 | TDP1 (0.69) | JMJD6RAB9ATDP1MAPTKMT2A | |
| SCHEMBL913728 | 0.66 | TDP1 (0.69) | JMJD6RAB9ATDP1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008135578-A1 | PYRAZOLO [3, 4-D] PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF INFLAMMATION AND/OR ALLERGIC CONDITIONS | GLAXO GROUP LIMITED (GB) | 2008-11-13 | — | — | WO | disclosed |