Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | PI4KA | P42356 | 1/20 | 0.59 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.59 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.59 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5007676 | 0.86 | XDH (0.48) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL14037083 | 0.85 | NPC1 (0.67) | KDM4EALDH1A1HSD17B10KMT2ATSHR | |
| SCHEMBL5009708 | 0.85 | GRM1 (0.51) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL5007641 | 0.85 | TSHR (0.52) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL30297992 | 0.84 | KDM4E (0.62) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL6287500 | 0.83 | KDM4E (0.59) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL5007643 | 0.81 | XDH (0.64) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL23274461 | 0.81 | ALDH1A1 (0.59) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL6281507 | 0.81 | KDM4E (0.58) | KDM4EALDH1A1HSD17B10MEN1KMT2A | |
| SCHEMBL5009824 | 0.81 | NPC1 (0.63) | KDM4EALDH1A1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080292561-A1 | Pyrazolo-Pyrimidine Derivatives as Anti-Inflammatory Agents | GLAXO GROUP LIMITED | 2008-11-27 | — | — | US | disclosed |
| US-20080292561-A1 | Pyrazolo-Pyrimidine Derivatives as Anti-Inflammatory Agents | GLAXO GROUP LIMITED | 2008-11-27 | — | — | US | disclosed |
| US-20080292561-A1 | Pyrazolo-Pyrimidine Derivatives as Anti-Inflammatory Agents | GLAXO GROUP LIMITED | 2008-11-27 | — | — | US | disclosed |
| WO-2007054294-A1 | PYRAZOLO-PYRIMIDINE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS | GLAXO GROUP LIMITED (GB) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080292561-A1 | Pyrazolo-Pyrimidine Derivatives as Anti-Inflammatory Agents | NOD1, FPR3, FPR1 | KDM4E 1193/4885ALDH1A1 1359/4885HSD17B10 3125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.