Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 12/20 | 0.85 |
| ▸ | PRKACG | P22612 | 12/20 | 0.85 |
| ▸ | PRKACB | P22694 | 12/20 | 0.85 |
| ▸ | CDK4 | P11802 | 4/20 | 0.85 |
| ▸ | CCND1 | P24385 | 4/20 | 0.85 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.85 |
| ▸ | CDK1 | P06493 | 3/20 | 0.85 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.85 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.85 |
| ▸ | PRKCA | P17252 | 3/20 | 0.85 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.85 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.85 |
| ▸ | GSK3B | P49841 | 2/20 | 0.85 |
| ▸ | PIM1 | P11309 | 2/20 | 0.85 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.85 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.85 |
| ▸ | CDK2 | P24941 | 2/20 | 0.85 |
| ▸ | PRKCB | P05771 | 2/20 | 0.85 |
| ▸ | PRKCH | P24723 | 2/20 | 0.85 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gf-109203 SCHEMBL338086 | 0.92 | PRKACA (1.00) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| Gf-109203 SCHEMBL29353725 | 0.92 | PRKACA (1.00) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| Gf-109203 SCHEMBL29534077 | 0.91 | PRKACA (0.98) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| Gf-109203 SCHEMBL1199513 | 0.91 | PRKACA (0.98) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL7826095 | 0.88 | PRKACA (0.81) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL7823516 | 0.88 | PRKACA (0.88) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9085417 | 0.87 | PRKACA (0.80) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL8074668 | 0.86 | PRKACA (1.00) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL1680137 | 0.84 | CAMK2D (1.00) | PRKACAPRKACGPRKACBCDK4CCND1 | |
| SCHEMBL9084210 | 0.84 | PRKACA (0.81) | PRKACAPRKACGPRKACBCDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008139152-A1 | N-OXIDE-CONTAINING PHARMACEUTICAL COMPOUNDS | SENTINEL ONCOLOGY LIMITED (GB) | 2008-11-20 | — | — | WO | disclosed |