Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1313273 | 0.83 | CHRM4 (0.39) | TSHRACKR3PDE3BPDE3ACHRM4 | |
| SCHEMBL1313786 | 0.82 | ACKR3 (0.44) | TSHRACKR3PDE3BPDE3ACHRM4 | |
| SCHEMBL1312796 | 0.78 | ACKR3 (0.41) | TSHRACKR3PDE3BPDE3ACHRM4 | |
| SCHEMBL1313259 | 0.69 | L3MBTL1 (0.48) | TSHRL3MBTL1HTTALDH1A1 | |
| SCHEMBL1312420 | 0.67 | DRD2 (0.54) | TSHRALDH1A1 | |
| SCHEMBL1313249 | 0.66 | TSHR (0.33) | TSHRGAAHPGDLMNAPOLB | |
| SCHEMBL1313278 | 0.64 | CHRM4 (0.39) | TSHRACKR3CHRM4ALDH1A1TLR9 | |
| SCHEMBL1312318 | 0.63 | DRD2 (0.49) | TSHRALDH1A1 | |
| SCHEMBL7124344 | 0.63 | DPP4 (0.36) | TSHRGAAHPGDLMNAPOLB | |
| SCHEMBL7125733 | 0.62 | MET (0.49) | PDGFRBFGFR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292613-A1 | DIHYDROINDOLINONE DERIVATIVES | Shanghai Institute of Pharmaceutical Industry (CN) | 2011-03-09 | — | — | EP | disclosed |