SCHEMBL1402279

SCHEMBL1402279

NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)O

nearest known ligand 0.42

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 1/20 0.42
CHRM4 P08173 1/20 0.42
CHRM5 P08912 1/20 0.42
CHRM1 P11229 1/20 0.42
CHRM3 P20309 1/20 0.42
PREP P48147 7/20 0.41
FAP Q12884 6/20 0.41
DPP4 P27487 4/20 0.41
F2 P00734 3/20 0.37
PRSS1 P07477 1/20 0.37
ACE P12821 2/20 0.37
CYP3A4 P08684 1/20 0.36
CYP2C9 P11712 1/20 0.36
PKM P14618 1/20 0.36
CYP2C19 P33261 1/20 0.36
ALDH1A1 P00352 1/20 0.36
DPP8 Q6V1X1 1/20 0.35
DPP9 Q86TI2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1402277 1.00 CHRM2 (0.42) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL29349875 0.92 DPP4 (0.43) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL29985759 0.91 PREP (0.44) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL30558194 0.88 FAP (0.40) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL8564777 0.88 DPP4 (0.46) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL8564779 0.88 DPP4 (0.46) CHRM2CHRM4CHRM5CHRM1CHRM3
SCHEMBL29544133 0.86 ACE (0.50) ACE
SCHEMBL29613141 0.86 ACE (0.50) ACE
SCHEMBL30439118 0.86 ACE (0.50) ACE
SCHEMBL29935652 0.86 CHRM3 (0.42) CHRM2CHRM4CHRM5CHRM1CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8080254-B2 OB fusion protein compositions and methods AMGEN, INC. (US) 2011-12-20 US claimed
US-20070224193-A1 METHODS OF INCREASING LEAN TISSUE MASS USING OB PROTEIN COMPOSITIONS AMGEN, INC. (US) 2007-09-27 US claimed
US-20070020284-A1 OB fusion protein compositions and methods AMGEN, INC. (US) 2007-01-25 US claimed
EP-0954588-B1 OB FUSION PROTEIN COMPOSITIONS AND METHODS AMGEN INC (US) 2007-01-17 EP claimed
CN-1335888-A OPG fusion protein compositions and methods AMGEN INC (US) 2002-02-13 CN claimed
EP-1127117-A1 OPG FUSION PROTEIN COMPOSITIONS AND METHODS Amgen Inc., (US) 2001-08-29 EP claimed
WO-2001018203-A1 OPG FUSION PROTEIN COMPOSITIONS AND METHODS AMGEN INC. (US) 2001-03-15 WO claimed
WO-2000063253-A1 AGP-1 FUSION PROTEIN COMPOSITIONS AND METHODS AMGEN INC. (US) 2000-10-26 WO claimed
EP-1961425-B1 METHODS AND ERYTHROPOEITIN ANALOGS FOR THE PREVENTION AND TREATMENT OF ANEMIA AMGEN INC (US) 2017-07-19 EP disclosed
US-20150209407-A1 METHODS FOR THE TREATMENT AND PREVENTION OF OSTEOPOROSIS AND BONE-RELATED DISEASES THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2015-07-30 US disclosed
US-20120322730-A1 METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF ANEMIA EGRIE JOAN C (US) 2012-12-20 US disclosed
US-8268588-B2 Methods and compositions for the prevention and treatment of anemia AMGEN INC. (US) 2012-09-18 US disclosed
US-8080254-B2 OB fusion protein compositions and methods AMGEN, INC. (US) 2011-12-20 US disclosed
US-20110256586-A1 Methods and Compositions for the Prevention and Treatment of Anemia EGRIE JOAN C 2011-10-20 US disclosed
WO-2001081405-A2 METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF ANEMIA AMGEN INC. (US) 2001-11-01 WO disclosed
EP-1140136-A2 COMPOSITIONS AND METHODS FOR THE PREVENTION OR TREATMENT OF CANCER AND BONE LOSS ASSOCIATED WITH CANCER Amgen Inc. (US) 2001-10-10 EP disclosed
EP-1127117-A1 OPG FUSION PROTEIN COMPOSITIONS AND METHODS Amgen Inc., (US) 2001-08-29 EP disclosed
WO-2001018203-A1 OPG FUSION PROTEIN COMPOSITIONS AND METHODS AMGEN INC. (US) 2001-03-15 WO disclosed
WO-2001017543-A2 COMPOSITIONS AND METHODS FOR THE PREVENTION OR TREATMENT OF CANCER AND BONE LOSS ASSOCIATED WITH CANCER AMGEN INC. (US) 2001-03-15 WO disclosed
WO-2000063253-A1 AGP-1 FUSION PROTEIN COMPOSITIONS AND METHODS AMGEN INC. (US) 2000-10-26 WO disclosed