Cycloguanil

Cycloguanil

SCHEMBL140230

CC1(C)N=C(N)N=C(N)N1c1ccc(Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DHFR P00374 5/20 1.00
LMNA P02545 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cycloguanil SCHEMBL2700759 0.98 DHFR (0.97) DHFRLMNA
Cycloguanil SCHEMBL1649173 0.97 DHFR (0.94) DHFRLMNA
Cycloguanil SCHEMBL9246965 0.93 DHFR (0.86) DHFR
Cycloguanil SCHEMBL14977281 0.90 DHFR (0.81) DHFRLMNA
SCHEMBL4104810 0.85 DHFR (0.73) DHFRLMNA
SCHEMBL4103257 0.83 DHFR (0.71) DHFRLMNA
SCHEMBL1938185 0.83 DHFR (1.00) DHFRLMNA
Chlorcycloguanil SCHEMBL8986158 0.83 DHFR (1.00) DHFR
SCHEMBL669914 0.82 DHFR (0.77) DHFR
SCHEMBL670885 0.81 DHFR (1.00) DHFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5356 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144251-A1 ANTIMICROBIAL NANOCLAYS COMPRISING CATIONIC ANTIMICROBIALS, METHOD OF PREPARATION AND USES THEREOF POLYAMYNA NANOTECH INC. (CA) 2026-05-28 US claimed
WO-2026086804-A1 MULTILAYER-REGULATED GENE EDITING SYSTEM AND USE THEREOF 自如基因科技(深圳)有限公司 2026-04-30 WO claimed
EP-4722714-A1 SIMULTANEOUS ANALYSIS OF FOOD-BORNE DOPING SUBSTANCES USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (VFD: VACCINE FOR FOODBORNE DOPING) Korea Institute of Science and Technology (KR) 2026-04-08 EP claimed
EP-3060043-B1 PESTICIDAL COMPOSITIONS AND RELATED METHODS CORTEVA AGRISCIENCE LLC (US) 2025-11-26 EP claimed
EP-3625238-B1 NOVEL SPIRO-LACTAM COMPOUNDS, PROCESS AND USES THEREOF UNIV DE COIMBRA (PT) 2025-11-26 EP claimed
EP-3578542-B1 COMPOSITIONS HAVING PESTICIDAL UTILITY AND PROCESSES RELATED THERETO CORTEVA AGRISCIENCE LLC (US) 2025-11-12 EP claimed
EP-3578543-B1 COMPOSITIONS COMPRISING MOLECULES HAVING PESTICIDAL UTILITY AND PROCESSES RELATED THERETO CORTEVA AGRISCIENCE LLC (US) 2025-08-20 EP claimed
EP-3578541-B1 COMPOSITIONS COMPRISING MOLECULES HAVING PESTICIDAL UTILITY, AND PROCESSES RELATED THERETO CORTEVA AGRISCIENCE LLC (US) 2025-05-28 EP claimed
EP-4521931-A1 BLACK SOLDIER FLY (HERMETIA ILLUCENS) LARVAE FRASS FORMULATIONS, COMBINATIONS AND USES Chonex, Inc. (US) 2025-03-19 EP claimed
WO-2024264013-A1 BIOAVAILABILITY ENHANCING IONIC LIQUID FORMULATIONS AND USES THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2024-12-26 WO claimed
EP-0504290-A4 INHIBITORS OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE 1993-03-24 EP claimed
EP-0504290-A1 INHIBITORS OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE. PROTOS CORP (US) 1992-09-23 EP claimed
US-5084449-A Bactericides and antiprotozoa agents DR. KARL THOMAE GMBH (DE) 1992-01-28 US claimed
WO-1991008667-A1 INHIBITORS OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE PROTOS CORPORATION (US) 1991-06-27 WO claimed
WO-1991008668-A1 INHIBITORS OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE PROTOS CORPORATION (US) 1991-06-27 WO claimed
US-4731359-A Prolonged action drug formulation UNIVERSITY OF SOUTHERN CALIFORNIA (US) 1988-03-15 US claimed
EP-0000291-B1 A PHARMACEUTICAL COMPOSITION FOR TROPICAL DISEASES University of Strathclyde (GB) 1981-09-30 EP claimed
EP-0001796-B1 ANTI-MALARIA DRUG HOECHST AKTIENGESELLSCHAFT (DE) 1981-06-10 EP claimed
US-4221779-A MALARIA BRITISH TECHNOLOGY GROUP LIMITED (GB) 1980-09-09 US claimed
EP-0001796-A1 Anti-malaria drug HOECHST AKTIENGESELLSCHAFT (DE) 1979-05-16 EP claimed