Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.69 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.58 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | PKLR | P30613 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8125309 | 0.84 | MEN1 (0.49) | MEN1KMT2ASHMT2NPC1PLA2G1B | |
| SCHEMBL9953246 | 0.81 | NPC1 (0.68) | MEN1KMT2ASHMT2NPC1PLA2G1B | |
| SCHEMBL742688 | 0.80 | NPC1 (0.67) | MEN1KMT2ASHMT2NPC1PLA2G1B | |
| SCHEMBL17792911 | 0.79 | SHMT2 (1.00) | MEN1KMT2ASHMT2NPC1PLA2G1B | |
| SCHEMBL740332 | 0.78 | MEN1 (0.63) | MEN1KMT2ASHMT2NPC1PLA2G1B | |
| SCHEMBL741553 | 0.75 | NPC1 (0.56) | MEN1KMT2ASHMT2NPC1PLA2G1B | |
| SCHEMBL858025 | 0.74 | NPC1 (0.61) | MEN1KMT2ASHMT2NPC1PLA2G1B | |
| SCHEMBL15212028 | 0.73 | ALPL (0.74) | MEN1KMT2ASHMT2NPC1PLA2G1B | |
| SCHEMBL740340 | 0.72 | NPC1 (0.64) | MEN1KMT2ASHMT2NPC1PLA2G1B | |
| SCHEMBL393051 | 0.71 | KMT2A (0.57) | MEN1KMT2ASHMT2NPC1PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2596793-A1 | Quinoline derivatives as PI3 kinase inhibitors | Glaxosmithkline LLC (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2008144464-A1 | QUINOLINE DERIVATIVES AS P13 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | WO | disclosed |