Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | PKLR | P30613 | 1/20 | 0.49 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14023926 | 0.84 | MEN1 (0.69) | MEN1KMT2APKLRSHMT2NPC1 | |
| SCHEMBL14023880 | 0.70 | FEN1 (0.42) | MEN1KMT2APIK3C3PIK3CDPIK3CA | |
| SCHEMBL10079156 | 0.67 | SERPINE1 (0.66) | MEN1KMT2APKLRALDH1A1GAA | |
| SCHEMBL8114928 | 0.67 | NPC1 (0.33) | MEN1KMT2ANPC1PLA2G1BATG4B | |
| SCHEMBL8127591 | 0.66 | SMN1; SMN2 (0.50) | NPC1PIK3C3ALDH1A1HTT | |
| SCHEMBL9953246 | 0.64 | NPC1 (0.68) | MEN1KMT2ASHMT2NPC1PLA2G1B | |
| SCHEMBL17792911 | 0.63 | SHMT2 (1.00) | MEN1KMT2ASHMT2NPC1PLA2G1B | |
| SCHEMBL13265977 | 0.63 | PKLR (0.46) | MEN1KMT2APKLRALDH1A1PFKFB3 | |
| SCHEMBL6087365 | 0.63 | CA1 (0.58) | PKLRGAAGFERAPOBEC3GHTT | |
| SCHEMBL742688 | 0.63 | NPC1 (0.67) | MEN1KMT2ASHMT2NPC1PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144463-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | WO | disclosed |