Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14025104 | 0.83 | ACACB (0.43) | SMN1; SMN2ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL15467001 | 0.79 | HRH3 (0.87) | HRH3SMN1; SMN2NOS3NOS1NOS2 | |
| SCHEMBL7555443 | 0.77 | HRH3 (0.56) | HRH3SMN1; SMN2NOS3NOS1NOS2 | |
| SCHEMBL7555448 | 0.77 | HRH3 (0.56) | HRH3SMN1; SMN2NOS3NOS1NOS2 | |
| SCHEMBL10159880 | 0.77 | HRH3 (0.65) | HRH3SMN1; SMN2NOS3NOS1NOS2 | |
| SCHEMBL10085217 | 0.74 | HRH3 (0.71) | HRH3SMN1; SMN2NOS3NOS1NOS2 | |
| SCHEMBL113089 | 0.74 | NCF1 (0.74) | HRH3SMN1; SMN2NOS3NOS1NOS2 | |
| SCHEMBL60797 | 0.74 | HRH3 (0.71) | HRH3SMN1; SMN2NOS3NOS1NOS2 | |
| SCHEMBL18805034 | 0.74 | HRH3 (0.71) | HRH3SMN1; SMN2NOS3NOS1NOS2 | |
| SCHEMBL13267163 | 0.74 | HRH3 (0.71) | HRH3SMN1; SMN2NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008143729-A2 | MACROLIDE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |