Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 6/20 | 0.47 |
| ▸ | CA1 | P00915 | 5/20 | 0.47 |
| ▸ | CA2 | P00918 | 5/20 | 0.47 |
| ▸ | CA12 | O43570 | 5/20 | 0.47 |
| ▸ | CTSC | P53634 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 3/20 | 0.40 |
| ▸ | USP1 | O94782 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14025091 | 0.77 | NOTUM (0.50) | MIFCA9CA1CA2CA12 | |
| SCHEMBL14023992 | 0.76 | NOTUM (0.51) | MIFCA9CA1CA2CA12 | |
| SCHEMBL14025114 | 0.74 | ESRRA (0.40) | CA9CA1CA2CA12CA4 | |
| SCHEMBL14023958 | 0.74 | NOTUM (0.39) | MIFDPP4RXRAGRIN1GRIN2B | |
| SCHEMBL22862590 | 0.74 | MIF (0.57) | MIFCA9CA1CA2CA12 | |
| SCHEMBL14025100 | 0.74 | PTGS2 (0.40) | MIFCA9CA1CA2CA12 | |
| SCHEMBL25045293 | 0.74 | MIF (0.56) | MIFCA9CA1CA2CA12 | |
| SCHEMBL14024030 | 0.72 | CDC25A (0.37) | MIFDPP4RXRAGRIN1GRIN2B | |
| SCHEMBL15060931 | 0.71 | CA12 (0.56) | MIFCA9CA1CA2CA12 | |
| SCHEMBL13527308 | 0.70 | BCHE (0.56) | MIFCA9CA1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008143729-A2 | MACROLIDE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |