Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 2/20 | 0.45 |
| ▸ | CTSC | P53634 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 9/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 9/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 9/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14025091 | 0.84 | NOTUM (0.50) | NOTUMPTGS2MIFP2RX7CA12 | |
| SCHEMBL14025100 | 0.81 | PTGS2 (0.40) | NOTUMPTGS2MIFRXRAGRIN1 | |
| SCHEMBL20026205 | 0.78 | NOTUM (0.49) | NOTUMROCK2RXRAGRIN1GRIN2B | |
| SCHEMBL14023943 | 0.76 | MIF (0.48) | ROCK2MIFCTSCRXRAGRIN1 | |
| SCHEMBL14023958 | 0.76 | NOTUM (0.39) | NOTUMPTGS2MIFRXRAGRIN1 | |
| SCHEMBL19062813 | 0.74 | SLC6A4 (0.41) | — | |
| SCHEMBL14024030 | 0.74 | CDC25A (0.37) | NOTUMPTGS2MIFRXRAGRIN1 | |
| SCHEMBL14025114 | 0.73 | ESRRA (0.40) | NOTUMCA12CA1CA2CA9 | |
| SCHEMBL20445076 | 0.73 | NOTUM (0.62) | NOTUMROCK2MIFRXRAGRIN1 | |
| SCHEMBL16479587 | 0.73 | MIF (0.63) | NOTUMROCK2MIFRXRAGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008143729-A2 | MACROLIDE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |