Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | MIF | P14174 | 3/20 | 0.36 |
| ▸ | CD74 | P04233 | 1/20 | 0.34 |
| ▸ | CDC25A | P30304 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 1/20 | 0.34 |
| ▸ | CDC25C | P30307 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | ESRRA | P11474 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | DDX3X | O00571 | 3/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14024030 | 0.85 | CDC25A (0.37) | NOTUMPTGS2MIFCD74CDC25A | |
| SCHEMBL14025114 | 0.77 | ESRRA (0.40) | NOTUMESRRA | |
| SCHEMBL14025091 | 0.77 | NOTUM (0.50) | NOTUMPTGS2MIFCD74DPP4 | |
| SCHEMBL14023992 | 0.76 | NOTUM (0.51) | NOTUMPTGS2MIFP2RX7RXRA | |
| SCHEMBL14023943 | 0.74 | MIF (0.48) | MIFDPP4RXRAGRIN1GRIN2B | |
| SCHEMBL14025100 | 0.74 | PTGS2 (0.40) | NOTUMPTGS2MIFDPP4P2RX7 | |
| SCHEMBL9634370 | 0.73 | NOTUM (0.50) | NOTUMMIFCD74ESRRAP2RX7 | |
| SCHEMBL14023881 | 0.70 | NOTUM (0.51) | NOTUM | |
| SCHEMBL17978569 | 0.68 | HTT (0.46) | NOTUMPTGS2ESRRA | |
| SCHEMBL20046658 | 0.67 | RXRA (0.41) | NOTUMPTGS2MIFCD74ESRRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008143729-A2 | MACROLIDE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | RIB-X PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |