Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.61 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | PRNP | P04156 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | AR | P10275 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1964286 | 0.91 | TRPV4 (0.56) | TRPV4MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL6944897 | 0.91 | TRPV4 (0.56) | TRPV4S1PR1MAPTMEN1KMT2A | |
| SCHEMBL15869350 | 0.91 | TRPV4 (0.56) | TRPV4MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL13127157 | 0.88 | TRPV4 (0.51) | TRPV4S1PR1MAPTMEN1KMT2A | |
| SCHEMBL5418640 | 0.86 | TRPV4 (0.59) | TRPV4S1PR1ALDH1A1DRD4AR | |
| SCHEMBL3743217 | 0.86 | TRPV4 (0.52) | TRPV4S1PR1MAPTMEN1KMT2A | |
| SCHEMBL18528829 | 0.86 | PTGDR2 (0.60) | TRPV4MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL21087453 | 0.85 | TRPV4 (0.51) | TRPV4S1PR1MAPTMEN1KMT2A | |
| SCHEMBL437358 | 0.85 | TRPV4 (0.54) | TRPV4S1PR1MAPTMEN1KMT2A | |
| SCHEMBL3920381 | 0.84 | TRPV4 (0.50) | TRPV4S1PR1GAAAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3782991-A1 | NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS | The Scripps Research Institute (US) | 2021-02-24 | — | — | EP | disclosed |
| US-10544136-B2 | Modulators of sphingosine phosphate receptors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-01-28 | — | — | US | disclosed |
| US-20190084947-A1 | NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS | THE SCRIPPS RESEARCH INSTITUTE | 2019-03-21 | — | — | US | disclosed |
| US-9975863-B2 | Modulators of sphingosine phosphate receptors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-05-22 | — | — | US | disclosed |
| US-20180009770-A1 | NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS | THE SCRIPPS RESEARCH INSTITUTE | 2018-01-11 | — | — | US | disclosed |
| US-20170050941-A1 | NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-02-23 | — | — | US | disclosed |
| US-9382217-B2 | Modulators of sphingosine phosphate receptors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-07-05 | — | — | US | disclosed |
| EP-2913326-A1 | Novel modulators of sphingosine phosphate receptors | THE SCRIPPS RESEARCH INSTITUTE (US) | 2015-09-02 | — | — | EP | disclosed |
| CN-102118972-B | Novel modulators of sphingosine phosphate receptors | SCRIPPS RESEARCH INST | 2015-06-10 | — | — | CN | disclosed |
| US-20150057307-A1 | NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-02-26 | — | — | US | disclosed |
| US-20070105911-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | CHIHIRO MASATOSHI | 2007-05-10 | — | — | US | disclosed |
| EP-0957915-B1 | THIAZOLE DERIVATIVES FOR INHIBITION OF CYTOKINE PRODUCTION AND OF CELL ADHESION | OTSUKA PHARMA CO LTD (JP) | 2005-02-02 | — | — | EP | disclosed |
| US-6790977-B2 | REACTING THE 3,4-DIALKOXY BENZONITRILE WITH AN ALKALI METAL HALIDE, FOLLOWED BY TREATING WITH HYDROCHLORIC ACID; HIGH YIELD AND A LOW COST STARTING MATERIAL | SINON CORPORATION (TW) | 2004-09-14 | — | — | US | disclosed |
| US-20040024239-A1 | Process for preparing 3,4-dihydroxy-benzonitrile | SINON CORPORATION (TW) | 2004-02-05 | — | — | US | disclosed |
| US-20040014792-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | OTSUKA PHARMACEUTICAL CO. LTD. | 2004-01-22 | — | — | US | disclosed |
| US-6583163-B2 | Using thiazole derivative | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2003-06-24 | — | — | US | disclosed |
| US-20020013469-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | OTSUKA PHARMACEUTICAL CO., LTD. | 2002-01-31 | — | — | US | disclosed |
| US-6291487-B1 | THIAZOLES SUBSTITUTED WITH A PHENYL AND A PYRIDYL GROUP | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2001-09-18 | — | — | US | disclosed |
| US-5639770-A | SUPEROXIDE INHIBITOR | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1997-06-17 | — | — | US | disclosed |
| EP-0600092-A1 | THIAZOLE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10544136-B2 | Modulators of sphingosine phosphate receptors | S1PR1, S1PR3, S1PR2 | TRPV4 191/4885S1PR1 1/4885MAPT 4693/4885 |
| US-20190084947-A1 | NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS | S1PR1, S1PR3, S1PR2 | TRPV4 192/4885S1PR1 1/4885MAPT 4675/4885 |
| US-20180009770-A1 | NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS | S1PR1, S1PR3, S1PR2 | TRPV4 158/4885S1PR1 1/4885MAPT 4538/4885 |
| US-20040014792-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | IL2, SELL, IL1RN | TRPV4 2674/4885S1PR1 829/4885MAPT 4360/4885 |
| US-20040024239-A1 | Process for preparing 3,4-dihydroxy-benzonitrile | PAH, HCN4, HPD | TRPV4 297/4885S1PR1 4688/4885MAPT 2879/4885 |
| US-20070105911-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | IL2, IL1RN, SELL | TRPV4 2515/4885S1PR1 729/4885MAPT 4491/4885 |
| US-20170050941-A1 | NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS | S1PR1, S1PR3, S1PR2 | TRPV4 192/4885S1PR1 1/4885MAPT 4675/4885 |
| US-20150057307-A1 | NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS | S1PR1, S1PR3, S1PR2 | TRPV4 192/4885S1PR1 1/4885MAPT 4675/4885 |
| US-20020013469-A1 | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion | IL2, SELL, IL1RN | TRPV4 2674/4885S1PR1 829/4885MAPT 4360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.