Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.56 |
| ▸ | AR | P10275 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1964286 | 0.93 | TRPV4 (0.56) | TRPV4ARMAPTKDM4EGAA | |
| SCHEMBL15869350 | 0.93 | TRPV4 (0.56) | TRPV4ARMAPTKDM4EGAA | |
| SCHEMBL1402437 | 0.91 | TRPV4 (0.61) | TRPV4ARMAPTKDM4EGAA | |
| SCHEMBL523551 | 0.86 | MPO (0.54) | TRPV4ARMAPTKDM4EALDH1A1 | |
| SCHEMBL17935910 | 0.85 | KDM4E (0.58) | MAPTKDM4EGAAMEN1ALDH1A1 | |
| SCHEMBL2163665 | 0.85 | AR (0.55) | ARMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL29490258 | 0.85 | AR (0.66) | ARMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL509522 | 0.85 | AR (0.66) | ARMAPTKDM4EMEN1ALDH1A1 | |
| SCHEMBL5531819 | 0.84 | AR (0.54) | ARMAPTALDH1A1HPGDUSP2 | |
| SCHEMBL1734101 | 0.84 | AR (0.54) | TRPV4ARMAPTALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12275723-B2 | Compounds and uses thereof | JANSSEN PHARMACEUTICA NV (BE) | 2025-04-15 | — | — | US | disclosed |
| US-20240400546-A1 | COMPOUNDS AND USES THEREOF | JANSSEN PHARMACEUTICA NV (BE) | 2024-12-05 | — | — | US | disclosed |
| US-20240300938-A1 | COMPOUNDS AND USES THEREOF | JANSSEN PHARMACEUTICA NV (BE) | 2024-09-12 | — | — | US | disclosed |
| US-11970486-B2 | Compounds and uses thereof | JANSSEN PHARMACEUTICA NV (BE) | 2024-04-30 | — | — | US | disclosed |
| US-20240124435-A1 | COMPOUNDS AND USES THEREOF | JANSSEN PHARMACEUTICA NV (BE) | 2024-04-18 | — | — | US | disclosed |
| CN-117777121-A | Compounds and uses thereof | 詹森药业有限公司 | 2024-03-29 | — | — | CN | disclosed |
| US-11873298-B2 | Compounds and uses thereof | JANSSEN PHARMACEUTICA NV (BE) | 2024-01-16 | — | — | US | disclosed |
| US-11873298-B2 | Compounds and uses thereof | JANSSEN PHARMACEUTICA NV (BE) | 2024-01-16 | — | — | US | disclosed |
| US-11873298-B2 | Compounds and uses thereof | JANSSEN PHARMACEUTICA NV (BE) | 2024-01-16 | — | — | US | disclosed |
| CN-110099898-B | Compounds and uses thereof | 优曼尼蒂治疗公司 | 2023-07-25 | — | — | CN | disclosed |
| EP-1601653-B1 | PROCESS FOR THE PRODUCTION OF SUBSTITUTED NICOTINIC ACID ESTERS | SYNGENTA PARTICIPATIONS AG (CH) | 2009-02-04 | — | — | EP | disclosed |
| US-20080274891-A1 | SUBSTITUTED PYRIDINE HERBICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2008-11-06 | — | — | US | disclosed |
| US-20080274891-A1 | SUBSTITUTED PYRIDINE HERBICIDES | SYNGENTA CROP PROTECTION, INC. (US) | 2008-11-06 | — | — | US | disclosed |
| US-7378375-B1 | Substituted pyridine herbicides | SYNGENTA CROP PROTECTION, INC. (US) | 2008-05-27 | — | — | US | disclosed |
| US-7378375-B1 | Substituted pyridine herbicides | SYNGENTA CROP PROTECTION, INC. (US) | 2008-05-27 | — | — | US | disclosed |
| EP-1080069-B1 | ANTHRANILIC ACID DERIVATIVES AS INHIBITORS OF THE CGMP-PHOSPHODIESTERASE | FUJISAWA PHARMACEUTICAL CO (JP) | 2003-03-19 | — | — | EP | disclosed |
| US-20020193614-A1 | Anthranilic acid derivatives as inhibitors of the CGMP-phosphodiesterase | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2002-12-19 | — | — | US | disclosed |
| US-6384080-B1 | TREATMENT AND/OR PREVENTION OF CERTAIN CARDIOVASCULAR DISORDERS, UROGENITAL DISORDERS, RESPIRATORY SYSTEM DISORDERS, DISORDERS OF GUT MOTILITY, SEXUAL DISORDERS, DIABETIC COMPLICATIONS, URTICARIA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-07 | — | — | US | disclosed |
| EP-1080069-A1 | ANTHRANILIC ACID DERIVATIVES AS INHIBITORS OF THE CGMP-PHOSPHODIESTERASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999054284-A1 | ANTHRANILIC ACID DERIVATIVES AS INHIBITORS OF THE CGMP-PHOSPHODIESTERASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124435-A1 | COMPOUNDS AND USES THEREOF | NLN, ACHE, CLN6 | TRPV4 464/4885AR 4802/4885MAPT 22/4885 |
| US-20240300938-A1 | COMPOUNDS AND USES THEREOF | NLN, ACHE, CLN6 | TRPV4 464/4885AR 4802/4885MAPT 22/4885 |
| US-20020193614-A1 | Anthranilic acid derivatives as inhibitors of the CGMP-phosphodiesterase | PDE3A, PDE2A, PDE5A | TRPV4 4134/4885AR 2696/4885MAPT 4706/4885 |
| US-11873298-B2 | Compounds and uses thereof | NLN, ACHE, CLN6 | TRPV4 464/4885AR 4802/4885MAPT 22/4885 |
| US-20240400546-A1 | COMPOUNDS AND USES THEREOF | NLN, ACHE, CLN6 | TRPV4 464/4885AR 4802/4885MAPT 22/4885 |
| US-20080274891-A1 | SUBSTITUTED PYRIDINE HERBICIDES | DDT, CYP1A1, CYP1B1 | TRPV4 1891/4885AR 3946/4885MAPT 3939/4885 |
| US-12275723-B2 | Compounds and uses thereof | NLN, ACHE, CLN6 | TRPV4 464/4885AR 4802/4885MAPT 22/4885 |
| US-11970486-B2 | Compounds and uses thereof | NLN, ACHE, CLN6 | TRPV4 464/4885AR 4802/4885MAPT 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.