Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | LTA4H | P09960 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | LSS | P48449 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 1/20 | 0.44 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4751222 | 0.87 | SMN1; SMN2 (0.58) | LMNAPKMKDM4EALDH1A1SIGMAR1 | |
| SCHEMBL15963172 | 0.87 | LTA4H (0.53) | LMNAPKMLTA4HALDH1A1SIGMAR1 | |
| SCHEMBL2904306 | 0.85 | SIGMAR1 (0.62) | LMNAPKMLTA4HALDH1A1SIGMAR1 | |
| SCHEMBL941871 | 0.80 | KDM4E (0.62) | KDM4EALDH1A1SIGMAR1LSSMEN1 | |
| SCHEMBL5734193 | 0.78 | SIGMAR1 (0.68) | KDM4EALDH1A1SIGMAR1LSSMEN1 | |
| SCHEMBL208118 | 0.78 | SIGMAR1 (0.68) | KDM4EALDH1A1SIGMAR1LSSMEN1 | |
| Hydrochloric Acid SCHEMBL4467874 | 0.77 | CXCR4 (0.68) | KDM4EALDH1A1SIGMAR1LSSMEN1 | |
| Hydrochloric Acid SCHEMBL2921947 | 0.77 | CXCR4 (0.68) | KDM4EALDH1A1SIGMAR1LSSMEN1 | |
| SCHEMBL156293 | 0.76 | SMN1; SMN2 (0.54) | PKMALDH1A1SIGMAR1SMN1; SMN2KMT2A | |
| SCHEMBL5696984 | 0.76 | LTA4H (0.46) | LMNAPKMLTA4HKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008136754-A1 | NOVEL BENZYL - 2 -OXO-PIPERAZINYL/ 7-OXO/5-OXA- [1,4] DIAZEPANYL/ 2 -OXO- TETRAHYDROPYRIMIDINYL DERIVATIVES | ASTRAZENECA AB (SE) | 2008-11-13 | — | — | WO | disclosed |