Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995183 | 0.98 | HTR1A (0.48) | HTR1AAHRHTR2CADRB2ADRA1A | |
| SCHEMBL17429447 | 0.92 | HTR1A (0.51) | HTR1AAHRHTR2CADRB2ADRA1A | |
| SCHEMBL10676145 | 0.86 | HTR2C (0.63) | HTR1AAHRHTR2CADRB2ADRA1A | |
| SCHEMBL10491761 | 0.84 | JAK2 (0.46) | HTR2CADRB2ADRB1HTR6JAK2 | |
| Hydrochloric Acid SCHEMBL11136214 | 0.82 | JAK2 (0.45) | HTR2CADRB2ADRB1HTR6JAK2 | |
| SCHEMBL3682166 | 0.82 | KDM4E (0.55) | HTR1AADRA1AJAK1 | |
| SCHEMBL11226328 | 0.80 | KDM4E (0.57) | HTR1AHTR2CADRA1A | |
| SCHEMBL31389951 | 0.79 | AHR (0.43) | HTR1AAHRHTR2CADRB2ADRA1A | |
| SCHEMBL31544235 | 0.78 | MEN1 (0.40) | HTR1AAHRHTR2CADRB2BCHE | |
| SCHEMBL27416543 | 0.78 | AHR (0.40) | HTR1AAHRADRB2ADRA1ABCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449480-B2 | Small molecule inhibitors of HER2 expression | BAYLOR COLLEGE OF MEDICINE (US) | 2008-11-11 | — | — | US | disclosed |