Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11219877 | 0.84 | DRD2 (0.52) | DRD2DRD3 | |
| SCHEMBL11226286 | 0.84 | DRD2 (0.44) | KDM4EATMDRD2HTR1AADRA1A | |
| SCHEMBL3682166 | 0.82 | KDM4E (0.55) | KDM4EATMHTR2AHTR1AADRA1A | |
| SCHEMBL10212688 | 0.82 | KDM4E (0.84) | KDM4EATMDRD2HTR2AHTR2C | |
| SCHEMBL14027792 | 0.80 | HTR1A (0.47) | HTR2CHTR1AADRA1A | |
| SCHEMBL8995183 | 0.79 | HTR1A (0.48) | HTR2CHTR1AADRA1A | |
| SCHEMBL10959130 | 0.78 | JAK2 (0.56) | DRD2HTR2AHTR2CKCNH2DRD3 | |
| SCHEMBL17429447 | 0.77 | HTR1A (0.51) | HTR2CHTR1AADRA1A | |
| SCHEMBL21369339 | 0.77 | DRD2 (0.55) | KDM4EATMDRD2HTR2AHTR2C | |
| SCHEMBL11065117 | 0.76 | BTK (0.45) | KDM4EHTR1AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4332808-A | Dopaminergically stimulating 4-substituted indoles | ROUSSEL UCLAF (FR) | 1982-06-01 | — | — | US | claimed |
| EP-0021924-A2 | Indole derivatives, process for their preparation, their use as medicines and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1981-01-07 | — | — | EP | claimed |
| US-4332808-A | Dopaminergically stimulating 4-substituted indoles | ROUSSEL UCLAF (FR) | 1982-06-01 | — | — | US | disclosed |