Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 2/20 | 0.49 |
| ▸ | HTR1B | P28222 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | HTR1F | P30939 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17429447 | 0.85 | HTR1A (0.51) | ADRA1AHTR1A | |
| SCHEMBL11226328 | 0.82 | KDM4E (0.57) | KDM4EATMADRA1AHTR1AHTR2A | |
| SCHEMBL14027792 | 0.82 | HTR1A (0.47) | ADRA1AHTR1AJAK1 | |
| SCHEMBL8995183 | 0.80 | HTR1A (0.48) | ADRA1AHTR1AJAK1ADRA1D | |
| SCHEMBL3256692 | 0.79 | KDM4E (0.83) | KDM4EATMHTR1DHTR1BCYP1A2 | |
| SCHEMBL30415306 | 0.79 | KDM4E (0.83) | KDM4EATMHTR1DHTR1BCYP1A2 | |
| SCHEMBL10676145 | 0.79 | HTR2C (0.63) | ADRA1AHTR1AAPPJAK1 | |
| Hydrochloric Acid SCHEMBL27732898 | 0.78 | KDM4E (0.81) | KDM4EATMHTR1DHTR1BCYP1A2 | |
| SCHEMBL3671316 | 0.76 | TRPV1 (0.47) | KDM4EATMHTR1DHTR1BCYP1A2 | |
| SCHEMBL14143336 | 0.76 | JAK1 (0.57) | KDM4EADRA1AJAK1BRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101730680-A | Has 5-HT 64 ' the compound that replaces of receptor affinity | MEMORY PHARM CORP | 2010-06-09 | — | — | CN | disclosed |
| EP-2162433-A2 | 4' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | Memory Pharmaceuticals Corporation (US) | 2010-03-17 | — | — | EP | disclosed |
| US-20080318941-A1 | 4' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | MEMORY PHARMACEUTICALS CORPORATION (US) | 2008-12-25 | — | — | US | disclosed |
| WO-2008147812-A2 | 4' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | MEMORY PHARMACEUTICALS CORPORATION (US) | 2008-12-04 | — | — | WO | disclosed |
| US-6255306-B1 | PSYCHOLOGICAL DISORDERS | MACOR JOHN E (US) | 2001-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080318941-A1 | 4' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | HTR6, HTR1B, HTR3B | KDM4E 1481/4885ATM 3846/4885ADRA1A 151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.