Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14028704 | 0.84 | NPC1 (0.43) | ALDH1A1NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL14046611 | 0.82 | NPC1 (0.51) | ALDH1A1NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL14028702 | 0.77 | ALDH1A3 (0.58) | ALDH1A1NPC1RAB9AGAAKDM4E | |
| SCHEMBL4951208 | 0.76 | ALDH1A3 (0.53) | ALDH1A1NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL2632253 | 0.72 | NPC1 (0.60) | ALDH1A1NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL2127102 | 0.72 | NPC1 (0.60) | ALDH1A1NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL14028701 | 0.72 | ALDH1A3 (0.51) | ALDH1A1NPC1RAB9AGAAKDM4E | |
| SCHEMBL8866551 | 0.70 | DHODH (0.68) | ALDH1A1NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL4952210 | 0.69 | PRSS1 (0.41) | ALDH1A1NPC1RAB9ANFKB1NFKB2 | |
| SCHEMBL10092621 | 0.68 | KDM1A (0.54) | ALDH1A1NPC1RAB9AGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432278-B2 | Dicationic imidazo[1,2-a]pyridines and 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridines as antiprotozoal agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2008-10-07 | — | — | US | disclosed |