Ginkgolide A

Ginkgolide A

SCHEMBL14029426

CC1C(=O)OC2CC34C5CC(C(C)(C)C)C36C(OC(=O)C6O)OC4(C(=O)O5)C21O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GLRA1 P23415 4/20 1.00
GLRA2 P23416 4/20 1.00
KMT2A Q03164 2/20 1.00
SMN1; SMN2 Q16637 1/20 1.00
MEN1 O00255 1/20 1.00
PTAFR P25105 4/20 0.67
CYP2C9 P11712 1/20 0.67
HSD17B10 Q99714 1/20 0.67
GUSB P08236 1/20 0.67
KDM4E B2RXH2 1/20 0.48
MAPK1 P28482 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ginkgolide A SCHEMBL340233 1.00 GLRA1 (1.00) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
Ginkgolide A SCHEMBL340234 1.00 GLRA1 (1.00) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
Ginkgolide A SCHEMBL16452772 1.00 GLRA1 (1.00) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
Ginkgolide A SCHEMBL29493161 1.00 GLRA1 (1.00) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
Ginkgolide A SCHEMBL13808829 1.00 GLRA1 (1.00) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
Ginkgolide A SCHEMBL24818724 1.00 GLRA1 (1.00) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
Ginkgolide A SCHEMBL13702916 1.00 GLRA1 (1.00) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
Ginkolide B SCHEMBL29384055 0.91 PTAFR (0.83) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
SCHEMBL13702686 0.87 GLRA1 (0.77) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
SCHEMBL13702895 0.87 GLRA1 (0.77) GLRA1GLRA2KMT2ASMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4053129-B1 GINKGOLIDE A FOR USE IN THE TREATMENT OF AUTISM CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE CHINESE ACAD OF SCIENCES (CN) 2025-05-14 EP claimed
CN-120142513-A Method for qualitatively analyzing small molecular compounds in Xinnaoning capsules by UPLC-MS technology 贵州景诚制药有限公司 2025-06-13 CN disclosed
CN-119074720-A Application of eupatorium adenophorum lactone A in preparation of medicines for preventing or treating pulmonary fibrosis 苏州大学 2024-12-06 CN disclosed
CN-115894515-A Method for integrated extraction, enrichment, separation and purification of effective components of ginkgo leaves in full industrial chain 李玉山 2023-04-04 CN disclosed
CN-1977868-B Ginkgo biloba leaf total terpene lactone extract, and its preparing method, medicinal composition and use ZHEJIANG HISUN PHARM CO LTD 2010-12-29 CN disclosed
CN-100479816-C Gingko total terpene lactone compounded medicinal composition, and preparing method and use thereof ZHEJIANG HAIZHENG PHARMACEUTIC (CN) 2009-04-22 CN disclosed
US-20080267948-A1 Croos-B Structure Binding Compounds CROSSBETA BIOSCIENCES B.V. (NL) 2008-10-30 US disclosed
CN-1977868-A Ginkgo biloba leaf total terpene lactone extract, and its preparing method, medicinal composition and use ZHEJIANG HAIZHENG PHARMACEUTIC (CN) 2007-06-13 CN disclosed
CN-1977840-A Gingko total terpene lactone compounded medicinal composition, and its preparing method and use ZHEJIANG HAIZHENG PHARMACEUTIC (CN) 2007-06-13 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080267948-A1 Croos-B Structure Binding Compounds CACYBP, TBCB, MYCBP GLRA1 2447/4885GLRA2 1807/4885KMT2A 4555/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.