Ginkgolide A

Ginkgolide A

SCHEMBL16452772

C[C@@H]1C(=O)O[C@H]2CC34[C@H]5C[C@@H](C(C)(C)C)[C@]36[C@@H](OC(=O)[C@@H]6O)O[C@@]4(C(=O)O5)[C@]21O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ GLRA1 P23415 4/20 1.00
▸ GLRA2 P23416 4/20 1.00
▸ KMT2A Q03164 2/20 1.00
▸ SMN1; SMN2 Q16637 1/20 1.00
▸ MEN1 O00255 1/20 1.00
▸ PTAFR P25105 4/20 0.67
▸ CYP2C9 P11712 1/20 0.67
▸ HSD17B10 Q99714 1/20 0.67
▸ GUSB P08236 1/20 0.67
▸ KDM4E B2RXH2 1/20 0.48
▸ MAPK1 P28482 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ginkgolide A SCHEMBL13808829 1.00 GLRA1 (1.00) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
Ginkgolide A SCHEMBL14029426 1.00 GLRA1 (1.00) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
Ginkgolide A SCHEMBL29493161 1.00 GLRA1 (1.00) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
Ginkgolide A SCHEMBL340234 1.00 GLRA1 (1.00) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
Ginkgolide A SCHEMBL13702916 1.00 GLRA1 (1.00) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
Ginkgolide A SCHEMBL24818724 1.00 GLRA1 (1.00) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
Ginkgolide A SCHEMBL340233 1.00 GLRA1 (1.00) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
Ginkolide B SCHEMBL29384055 0.91 PTAFR (0.83) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
SCHEMBL13702686 0.87 GLRA1 (0.77) GLRA1GLRA2KMT2ASMN1; SMN2MEN1
SCHEMBL13702895 0.87 GLRA1 (0.77) GLRA1GLRA2KMT2ASMN1; SMN2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9084755-B2 Method for extracting and separating ginkgolides CHENGDU BAIYU TECHNOLOGY PHARMACY CO., LTD. (CN) 2015-07-21 — — US disclosed
US-9084755-B2 Method for extracting and separating ginkgolides CHENGDU BAIYU TECHNOLOGY PHARMACY CO., LTD. (CN) 2015-07-21 — — US disclosed
US-20150044311-A1 METHOD FOR EXTRACTING AND SEPARATING GINKGOLIDES CHENGDU BAIYU PHARMACEUTICAL CO., LTD. (CN) 2015-02-12 — — US disclosed
US-20150044311-A1 METHOD FOR EXTRACTING AND SEPARATING GINKGOLIDES CHENGDU BAIYU PHARMACEUTICAL CO., LTD. (CN) 2015-02-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150044311-A1 METHOD FOR EXTRACTING AND SEPARATING GINKGOLIDES COG8, CYP8B1, GTPBP10 GLRA1 1288/4885GLRA2 1355/4885KMT2A 4576/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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