Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 14/20 | 0.39 |
| ▸ | PRKCG | P05129 | 11/20 | 0.39 |
| ▸ | PRKCB | P05771 | 11/20 | 0.39 |
| ▸ | PRKCA | P17252 | 11/20 | 0.39 |
| ▸ | IDH1 | O75874 | 2/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.38 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
| ▸ | GMNN | O75496 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4686966 | 0.88 | GSK3B (0.51) | GSK3BPRKCGPRKCBPRKCAGSK3A | |
| SCHEMBL14032117 | 0.85 | GSK3B (0.46) | CAMK2DGSK3BPRKCGPRKCBPRKCA | |
| SCHEMBL8302978 | 0.81 | GSK3B (0.59) | CAMK2DGSK3BPRKCGPRKCBPRKCA | |
| SCHEMBL14032339 | 0.80 | CAMK2D (0.39) | CAMK2DGSK3BPRKCGPRKCBPRKCA | |
| SCHEMBL14050971 | 0.76 | GSK3B (0.46) | CAMK2DGSK3BPRKCGPRKCBPRKCA | |
| SCHEMBL3781580 | 0.70 | GSK3B (0.66) | GSK3BPRKCGPRKCBPRKCAGSK3A | |
| SCHEMBL8300692 | 0.70 | GSK3B (0.47) | GSK3BPRKCGPRKCBPRKCAGSK3A | |
| SCHEMBL16156822 | 0.69 | PSEN1 (0.38) | TP53MAPTMAPK1HTT | |
| SCHEMBL5752565 | 0.68 | GSK3B (0.54) | GSK3BPRKCGPRKCBPRKCAIDH1 | |
| SCHEMBL5757844 | 0.68 | GSK3B (0.67) | GSK3BPRKCGPRKCBPRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7439363-B2 | Substituted indazoly(indoly)maleimide derivatives as kinase inhibitors | JANSSEN PARMACEUTICA N.V. (BE) | 2008-10-21 | — | — | US | disclosed |
| US-7439363-B2 | Substituted indazoly(indoly)maleimide derivatives as kinase inhibitors | JANSSEN PARMACEUTICA N.V. (BE) | 2008-10-21 | — | — | US | disclosed |