Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 11/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | CDK4 | P11802 | 2/20 | 0.47 |
| ▸ | CCND1 | P24385 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | RGS12 | O14924 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14032339 | 0.89 | CAMK2D (0.39) | GSK3BGSK3ACDK4CCND1CDK2 | |
| SCHEMBL8302980 | 0.88 | GSK3B (0.55) | GSK3BPRKCAPRKCGPRKCB | |
| SCHEMBL14032411 | 0.82 | GSK3B (0.43) | GSK3BPRKCAPRKCGPRKCB | |
| SCHEMBL4686966 | 0.81 | GSK3B (0.51) | GSK3BGSK3ACDK4CCND1CDK2 | |
| SCHEMBL3781580 | 0.79 | GSK3B (0.66) | GSK3BGSK3ACDK4CCND1CDK2 | |
| SCHEMBL5752565 | 0.78 | GSK3B (0.54) | GSK3BGSK3ACDK4CCND1CDK2 | |
| SCHEMBL5757844 | 0.78 | GSK3B (0.67) | GSK3BGSK3ACDK4CCND1CDK2 | |
| SCHEMBL4689265 | 0.78 | GSK3B (0.50) | GSK3BGSK3ACDK4CCND1CDK2 | |
| SCHEMBL4691089 | 0.78 | GSK3B (0.50) | GSK3BGSK3ACDK4CCND1CDK2 | |
| SCHEMBL5754325 | 0.77 | GSK3B (0.69) | GSK3BGSK3ACDK4CCND1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1654255-B1 | SUBSTITUTED INDAZOLYL(INDOLYL)MALEIMIDE DERIVATIVES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-27 | — | — | EP | disclosed |
| WO-2005000836-A1 | SUBSTITUTED INDAZOLYL(INDOLYL)MALEIMIDE DERIVATIVES AS KINASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-01-06 | — | — | WO | disclosed |