Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL19858647 | 0.98 | TSHR (0.42) | TSHRTHRBCHRM5CHRM1CHRM3 | |
| SCHEMBL165948 | 0.98 | TSHR (0.42) | TSHRTHRBCHRM5CHRM1CHRM3 | |
| Water SCHEMBL28062403 | 0.97 | TSHR (0.40) | TSHRTHRBCHRM5CHRM1CHRM3 | |
| Water SCHEMBL22773559 | 0.97 | TSHR (0.41) | TSHRTHRBCHRM5CHRM1CHRM3 | |
| Water SCHEMBL15392730 | 0.96 | TSHR (0.41) | TSHRTHRBCHRM5CHRM1CHRM3 | |
| Water SCHEMBL28590852 | 0.95 | TSHR (0.38) | TSHRTHRBCHRM5CHRM1CHRM3 | |
| Water SCHEMBL15392417 | 0.94 | TSHR (0.43) | TSHRTHRBCHRM5CHRM1CHRM3 | |
| SCHEMBL1616014 | 0.94 | TSHR (0.41) | TSHRTHRBCHRM5CHRM1CHRM3 | |
| Water SCHEMBL15393133 | 0.94 | TSHR (0.45) | TSHRTHRBCHRM5CHRM1CHRM3 | |
| Water SCHEMBL15393059 | 0.93 | TSHR (0.47) | TSHRTHRBCHRM5CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2074 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-121895501-B | Thermoelectric hydrogel based on synergistic enhancement of zwitterions and polar solvents, method and application thereof | TAIYUAN UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-121824995-B | Marine antifouling conductive hydrogel and preparation method and application thereof | NORTHEASTERN UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122060473-A | Bonding hyperbranched nanorod cementing wall-fixing agent and preparation method and application thereof | 中国石油大学(华东) | 2026-05-19 | — | — | CN | claimed |
| CN-122055142-A | Improved pill design for administration to ruminants and uses thereof | 反刍动物生物科技有限公司 | 2026-05-15 | — | — | CN | claimed |
| CN-121760214-B | Moisture-absorbing sweat-discharging sweater fabric and preparation process thereof | 昆山华阳新材料股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-4188489-B1 | METHODS OF ALTERING THE SURFACE ENERGY OF COMPONENTS OF A MESH NEBULIZER | ACULON INC (US) | 2026-04-15 | — | — | EP | claimed |
| CN-121574388-A | Eutectoid gel and preparation method and application thereof | 陕西师范大学 | 2026-02-27 | — | — | CN | claimed |
| CN-121577878-A | Microorganism label-free rapid detection system, method and application thereof | 福州大学 | 2026-02-27 | — | — | CN | claimed |
| CN-121574483-A | Cooling hydrogel and preparation method thereof | 北京科技大学 | 2026-02-27 | — | — | CN | claimed |
| US-20260035576-A1 | ANTI-FOULING COATINGS FOR ELECTROCHEMICAL BIOSENSORS | UNIV MCMASTER (CA) | 2026-02-05 | — | — | US | claimed |
| EP-1409629-A1 | USE OF GRAFT POLYMERS IN FABRIC CLEANING | UNILEVER PLC (GB) | 2004-04-21 | — | — | EP | claimed |
| US-20030161804-A1 | Self-adhesive cationic or amphoteric free-radical polymers and cosmetic use thereof | L'OREAL (FR) | 2003-08-28 | — | — | US | claimed |
| WO-2003040218-A1 | POROUS POLYMER FILMS | POLYMERAT PTY LTD (AU) | 2003-05-15 | — | — | WO | claimed |
| WO-2003010267-A1 | USE OF POLYMERS IN FABRICS CLEANING | UNILEVER PLC (GB) | 2003-02-06 | — | — | WO | claimed |
| US-6403073-B1 | MIXTURE CONTAINING ADDITION POLYMER | L'OREAL S.A. (FR) | 2002-06-11 | — | — | US | claimed |
| EP-0889940-B1 | ELECTROSPRAYABLE RELEASE COATING | MINNESOTA MINING & MFG (US) | 2000-05-03 | — | — | EP | claimed |
| EP-0889940-A1 | ELECTROSPRAYABLE RELEASE COATING | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1999-01-13 | — | — | EP | claimed |
| US-5858545-A | COMPRISING AN UNSATURATED MONOMER, A POLYSILOXANE HAVING UNSATURATED END GROUPS AND ONE OR MORE NONVOLATILE CONDUCTIVITY ENHANCER SOLUBLE IN THE MONOMER AND NOT INTERFERING WITH THE COPOLYMERIZATION | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1999-01-12 | — | — | US | claimed |
| WO-1997035941-A1 | ELECTROSPRAYABLE RELEASE COATING | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1997-10-02 | — | — | WO | claimed |
| US-5523367-A | DISPOSABLE PRODUCTS | PHILLIPS PETROLEUM COMPANY (US) | 1996-06-04 | — | — | US | claimed |