Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27365079 | 0.89 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1TP53POLBGAA | |
| SCHEMBL28738942 | 0.81 | — | — | |
| SCHEMBL65441 | 0.81 | ALDH1A1 (0.50) | SMN1; SMN2ALDH1A1GAAKDM4EMEN1 | |
| SCHEMBL24519291 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1TP53POLBGAA | |
| SCHEMBL9370493 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1TP53POLBGAA | |
| Hydrochloric Acid SCHEMBL28912856 | 0.79 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1GAAMEN1KMT2A | |
| SCHEMBL65325 | 0.79 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1POLBGAAKDM4E | |
| Hydrochloric Acid SCHEMBL4391137 | 0.79 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1GAAMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27501008 | 0.77 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1GAAKDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL28645405 | 0.77 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1GAAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442694-B2 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | PFIZER INC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442694-B2 | Diazabicyclic compounds useful in the treatment of CNS and other disorders | PFIZER INC (US) | 2008-10-28 | — | — | US | disclosed |