Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14033251 | 0.87 | MAPT (0.55) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL377638 | 0.84 | GAA (0.65) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| Bromide SCHEMBL1858718 | 0.82 | GAA (0.63) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL2624372 | 0.81 | GAA (0.62) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL5386249 | 0.81 | MAPT (0.74) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL15942681 | 0.81 | ALOX15 (0.66) | MAPTALDH1A1PTPN1MEN1KMT2A | |
| Alcohol SCHEMBL28230448 | 0.81 | GAA (0.61) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL11420513 | 0.81 | LTA4H (0.57) | ALDH1A1GAAL3MBTL1MEN1KMT2A | |
| SCHEMBL13399183 | 0.81 | KDM4E (0.58) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL8623784 | 0.81 | GAA (0.57) | MAPTALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |