Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4099373 | 1.00 | LMNA (0.54) | LMNAGAAKDM4EOPRD1SLC6A9 | |
| SCHEMBL4095319 | 1.00 | LMNA (0.54) | LMNAGAAKDM4EOPRD1SLC6A9 | |
| SCHEMBL23599619 | 0.87 | HRH3 (0.47) | LMNAGAAKDM4EHRH3 | |
| SCHEMBL4094064 | 0.86 | OPRD1 (0.44) | LMNAGAAKDM4EOPRD1SLC6A9 | |
| SCHEMBL4099362 | 0.86 | OPRD1 (0.44) | LMNAGAAKDM4EOPRD1SLC6A9 | |
| SCHEMBL13724540 | 0.84 | SLC6A2 (0.50) | LMNAGAAKDM4EOPRD1ALDH1A1 | |
| SCHEMBL13724968 | 0.84 | SLC6A2 (0.50) | LMNAGAAKDM4EOPRD1ALDH1A1 | |
| SCHEMBL2537196 | 0.80 | MEN1 (0.58) | OPRD1SLC6A9MEN1KMT2ASLC6A3 | |
| SCHEMBL4146000 | 0.80 | MEN1 (0.58) | OPRD1SLC6A9MEN1KMT2ASLC6A3 | |
| SCHEMBL2315253 | 0.80 | MEN1 (0.58) | OPRD1SLC6A9MEN1KMT2ASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134036-A1 | ALPHA-SUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-α]PYRIMIDINE AMIDE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |