Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.44 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.44 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13724540 | 1.00 | SLC6A2 (0.50) | SLC6A2SLC6A3SLC6A4ALDH1A1KDM4E | |
| SCHEMBL4095319 | 0.84 | LMNA (0.54) | SLC6A2SLC6A3SLC6A4ALDH1A1KDM4E | |
| SCHEMBL4099373 | 0.84 | LMNA (0.54) | SLC6A2SLC6A3SLC6A4ALDH1A1KDM4E | |
| SCHEMBL14035403 | 0.84 | LMNA (0.54) | SLC6A2SLC6A3SLC6A4ALDH1A1KDM4E | |
| SCHEMBL13789612 | 0.83 | CHRM2 (0.53) | SLC6A2SLC6A3SLC6A4ALDH1A1CHRM2 | |
| SCHEMBL26891505 | 0.82 | ALDH1A1 (0.50) | SLC6A2SLC6A3SLC6A4ALDH1A1KDM4E | |
| SCHEMBL13724549 | 0.80 | ALDH1A1 (0.54) | SLC6A2SLC6A3SLC6A4ALDH1A1KDM4E | |
| SCHEMBL13724839 | 0.80 | ALDH1A1 (0.54) | SLC6A2SLC6A3SLC6A4ALDH1A1KDM4E | |
| SCHEMBL4094064 | 0.80 | OPRD1 (0.44) | ALDH1A1KDM4EMEN1LMNAKMT2A | |
| SCHEMBL4099362 | 0.80 | OPRD1 (0.44) | ALDH1A1KDM4EMEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215778-A1 | Alpha-substituted Arylmethyl Piperazine Pyrazolo [1,5-alpha]Pyrimidine Amide Derivatives | PANACOS PHARMACEUTICALS, INC. (US) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215778-A1 | Alpha-substituted Arylmethyl Piperazine Pyrazolo [1,5-alpha]Pyrimidine Amide Derivatives | THPO, DPYD, TPMT | SLC6A2 4212/4885SLC6A3 4118/4885SLC6A4 3834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.