Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGXT | P21549 | 1/20 | 0.64 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.55 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.55 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5319433 | 0.89 | AGXT (0.72) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL3150291 | 0.81 | AGXT (0.68) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL5935789 | 0.81 | AGXT (0.54) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL10736150 | 0.79 | AGXT (0.65) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL3413507 | 0.79 | CYP2A6 (0.64) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL2088811 | 0.78 | AGXT (0.68) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL13760611 | 0.77 | AGXT (0.62) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL6963172 | 0.76 | CYP2A6 (0.60) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL7340276 | 0.76 | CYP2A6 (0.60) | AGXTCYP2A6ASIC3LOXL2ADRB2 | |
| SCHEMBL14106986 | 0.75 | AGXT (0.58) | AGXTCYP2A6ASIC3LOXL2ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287398-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287398-A1 | COLD MENTHOL RECEPTOR-1 ANTAGONISTS | TRPM8, TRPM5, TRPM7 | AGXT 4644/4885CYP2A6 1401/4885ASIC3 219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.