Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 4/20 | 0.43 |
| ▸ | CCND1 | P24385 | 4/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.36 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1403602 | 1.00 | MAOB (0.48) | MAOBGSK3BKDM4ECDK4CCND1 | |
| SCHEMBL29706697 | 0.83 | GSK3B (0.54) | MAOBGSK3BKDM4EABCG2ALDH1A1 | |
| SCHEMBL161792 | 0.83 | GSK3B (0.54) | MAOBGSK3BKDM4EABCG2ALDH1A1 | |
| SCHEMBL97241 | 0.79 | MAOB (0.43) | MAOBGSK3BKDM4EABCG2ALDH1A1 | |
| SCHEMBL97242 | 0.79 | MAOB (0.43) | MAOBGSK3BKDM4EABCG2ALDH1A1 | |
| SCHEMBL13972664 | 0.78 | MAOB (0.50) | MAOBGSK3BKDM4EABCG2PKM | |
| SCHEMBL3570479 | 0.77 | MAOB (0.60) | MAOBGSK3BKDM4EABCG2ALDH1A1 | |
| SCHEMBL4168160 | 0.77 | MAOB (0.47) | MAOBGSK3BKDM4EABCG2ALDH1A1 | |
| SCHEMBL3570478 | 0.77 | MAOB (0.60) | MAOBGSK3BKDM4EABCG2ALDH1A1 | |
| SCHEMBL4168158 | 0.77 | MAOB (0.47) | MAOBGSK3BKDM4EABCG2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10899750-B2 | Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP. (US) | 2021-01-26 | — | — | US | disclosed |
| US-20180009793-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP (US) | 2018-01-11 | — | — | US | disclosed |
| US-20180009793-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP (US) | 2018-01-11 | — | — | US | disclosed |
| US-9663471-B2 | Pyrazole derivatives as modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORPORATION (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663471-B2 | Pyrazole derivatives as modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORPORATION (US) | 2017-05-30 | — | — | US | disclosed |
| US-9663471-B2 | Pyrazole derivatives as modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORPORATION (US) | 2017-05-30 | — | — | US | disclosed |
| EP-2292227-B1 | Pyrazole derivatives modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP (US) | 2016-08-24 | — | — | EP | disclosed |
| EP-2292227-B1 | Pyrazole derivatives modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP (US) | 2016-08-24 | — | — | EP | disclosed |
| US-20140256780-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORPORATION (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140256727-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2014-09-11 | — | — | US | disclosed |
| US-7250437-B2 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP. (US) | 2007-07-31 | — | — | US | disclosed |
| US-7250437-B2 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity | ANGION BIOMEDICA CORP. (US) | 2007-07-31 | — | — | US | disclosed |
| US-7192976-B2 | 3-substituted pyrazoles; cell proliferation and angiogenesis promoters; antiapoptotosis and antifibrosis activity | ANGION BIOMEDICA CORPORATION (US) | 2007-03-20 | — | — | US | disclosed |
| US-7192976-B2 | 3-substituted pyrazoles; cell proliferation and angiogenesis promoters; antiapoptotosis and antifibrosis activity | ANGION BIOMEDICA CORPORATION (US) | 2007-03-20 | — | — | US | disclosed |
| US-7192976-B2 | 3-substituted pyrazoles; cell proliferation and angiogenesis promoters; antiapoptotosis and antifibrosis activity | ANGION BIOMEDICA CORPORATION (US) | 2007-03-20 | — | — | US | disclosed |
| EP-1572199-A2 | PYRAZOLE DERIVATIVES MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | Angion Biomedica Corp. (US) | 2005-09-14 | — | — | EP | disclosed |
| US-20050192331-A1 | Administering 3-substituted pyrazoles for therapy of fibrotic liver disease; hepatic isehemia-reperfusion injury; cerebral infarction; ischemic heart disease; renal disease; lung (pulmonary) fibrosis; liver fibrosis associated with hepatitis C, hepatitis B, delta hepatitis, chronic alcoholism | ANGION BIOMEDICA CORP. | 2005-09-01 | — | — | US | disclosed |
| US-20050113369-A1 | Pyrrazoles connnected to a carbocyclic ring by a vinylene, butadienylene or hexatrienylene bridge, e.g. 3(5)-[2-(2-chloro-5-trifluoromethylphenyl)vinyl]-1H-pyrazole; compounds exhibit antifibrotic and antiapoptotic activities | ANGION BIOMEDICA CORP. | 2005-05-26 | — | — | US | disclosed |
| US-20040180882-A1 | 3-substituted pyrazoles; cell proliferation and angiogenesis promoters; antiapoptotosis and antifibrosis activity | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-09-16 | — | — | US | disclosed |
| WO-2004058721-A2 | PYRAZOLE DERIVATIVES MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | ANGION BIOMEDICA CORP. (US) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050113369-A1 | Pyrrazoles connnected to a carbocyclic ring by a vinylene, butadienylene or hexatrienylene bridge, e.g. 3(5)-[2-(2-chloro-5-trifluoromethylphenyl)vinyl]-1H-pyrazole; compounds exhibit antifibrotic and antiapoptotic activities | HGF, HDGF, HGFAC | MAOB 3308/4885GSK3B 2757/4885KDM4E 4079/4885 |
| US-20140256727-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, HGFAC | MAOB 1632/4885GSK3B 1068/4885KDM4E 4796/4885 |
| US-10899750-B2 | Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity | HGF, HDGF, HGFAC | MAOB 2089/4885GSK3B 925/4885KDM4E 4780/4885 |
| US-20050192331-A1 | Administering 3-substituted pyrazoles for therapy of fibrotic liver disease; hepatic isehemia-reperfusion injury; cerebral infarction; ischemic heart disease; renal disease; lung (pulmonary) fibrosis; liver fibrosis associated with hepatitis C, hepatitis B, delta hepatitis, chronic alcoholism | HGF, HDGF, PDGFRB | MAOB 308/4885GSK3B 428/4885KDM4E 4794/4885 |
| US-20180009793-A1 | METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, HGFAC | MAOB 1632/4885GSK3B 1068/4885KDM4E 4796/4885 |
| US-20140256780-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY | HGF, HDGF, MET | MAOB 2066/4885GSK3B 1150/4885KDM4E 4526/4885 |
| US-20040180882-A1 | 3-substituted pyrazoles; cell proliferation and angiogenesis promoters; antiapoptotosis and antifibrosis activity | HGF, HDGF, VEGFA | MAOB 1917/4885GSK3B 598/4885KDM4E 3476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.