Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14010022 | 0.82 | KDM4E (0.36) | KDM4EHSP90AA1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14533463 | 0.81 | KDM4E (0.40) | KDM4EHSP90AA1SMN1; SMN2MAPTTP53 | |
| SCHEMBL13310330 | 0.79 | IDO1 (0.40) | KDM4EHSP90AA1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3395413 | 0.77 | HSP90AA1 (0.45) | KDM4EHSP90AA1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL31330058 | 0.76 | KDM4E (0.44) | KDM4EHSP90AA1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21661374 | 0.69 | HSP90AA1 (0.45) | KDM4EHSP90AA1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL11926120 | 0.69 | COMT (0.40) | KDM4EHSP90AA1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3157064 | 0.69 | NSD2 (0.39) | KDM4ESMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL7566187 | 0.67 | L3MBTL1 (0.58) | KDM4EHSP90AA1SMN1; SMN2MAPTTP53 | |
| SCHEMBL7996851 | 0.67 | L3MBTL1 (0.58) | KDM4EHSP90AA1SMN1; SMN2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080293646-A1 | MACROLIDES | PFIZER INC | 2008-11-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293646-A1 | MACROLIDES | MRPL21, CFTR, RPS21 | KDM4E 3019/4885HSP90AA1 1927/4885SMN1; SMN2 2448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.