Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP4 | P15090 | 5/20 | 0.46 |
| ▸ | HTR3A | P46098 | 9/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12748717 | 0.89 | AKR1C3 (0.46) | FABP4HTR3AAKR1C3AKR1C1HTR6 | |
| SCHEMBL12748722 | 0.79 | AKR1C3 (0.48) | FABP4HTR3AAKR1C3AKR1C1HTR6 | |
| SCHEMBL12748700 | 0.79 | PTGDR2 (0.54) | AKR1C3AKR1C1HTR6PTGDR2HTR2A | |
| SCHEMBL12748723 | 0.78 | ACLY (0.45) | FABP4AKR1C3AKR1C1HTR6PTGDR2 | |
| SCHEMBL15556917 | 0.78 | HTR3A (0.57) | HTR3AAKR1C3AKR1C1HTR6PTGDR2 | |
| SCHEMBL1468385 | 0.77 | AKR1C3 (0.60) | AKR1C3AKR1C1HTR6PTGDR2PTGDR | |
| SCHEMBL12748709 | 0.76 | AKR1C3 (0.50) | AKR1C3AKR1C1HTR6PTGDR2HTR2A | |
| SCHEMBL12748697 | 0.75 | AKR1C3 (0.68) | AKR1C3AKR1C1HTR6PTGDR2 | |
| SCHEMBL15557431 | 0.74 | HTR3A (0.58) | HTR3AAKR1C3AKR1C1HTR6 | |
| SCHEMBL12748713 | 0.74 | HTR6 (0.54) | AKR1C3AKR1C1HTR6PTGDR2PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1990335-A1 | 17 BETA HSD TYPE 5 INHIBITOR | Astellas Pharma Inc. (JP) | 2008-11-12 | — | — | EP | disclosed |