Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PPP5C | P53041 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GJB2 | P29033 | 4/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14569004 | 0.89 | GJB2 (0.42) | SMN1; SMN2PPP5CALDH1A1TDP1GJB2 | |
| SCHEMBL12000845 | 0.83 | SMN1; SMN2 (0.42) | SMN1; SMN2PPP5CALDH1A1TDP1GJB2 | |
| SCHEMBL14642972 | 0.81 | PPP5C (0.43) | SMN1; SMN2PPP5CALDH1A1TDP1GJB2 | |
| SCHEMBL14580119 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2PPP5CALDH1A1TDP1GJB2 | |
| SCHEMBL12000846 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2PPP5CALDH1A1TDP1GJB2 | |
| SCHEMBL7794271 | 0.79 | ALDH1A1 (0.44) | SMN1; SMN2PPP5CALDH1A1TDP1GJB2 | |
| SCHEMBL7794269 | 0.79 | ALDH1A1 (0.44) | SMN1; SMN2PPP5CALDH1A1TDP1GJB2 | |
| SCHEMBL16392610 | 0.79 | SMN1; SMN2 (0.39) | SMN1; SMN2PPP5CALDH1A1TDP1GJB2 | |
| SCHEMBL12000844 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2PPP5CALDH1A1TDP1GJB2 | |
| SCHEMBL5008877 | 0.77 | ALDH1A1 (0.41) | SMN1; SMN2PPP5CALDH1A1TDP1GJB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008141079-A1 | TETRAHYDROFURO [3 4-D] DIOXOLANE COMPOUNDS FOR USE IN THE TREATMENT OF VIRAL INFECTIONS AND CANCER | BIOCRYST PHARMACEUTICALS, INC. (US) | 2008-11-20 | — | — | WO | disclosed |