Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN5 | P54829 | 5/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26939102 | 0.81 | KIF11 (0.45) | KIF11TAS1R3TAS1R1 | |
| SCHEMBL9630722 | 0.77 | HSD17B1 (0.42) | KIF11 | |
| SCHEMBL10304793 | 0.77 | KIF11 (0.48) | KIF11RXRARXRBRXRG | |
| SCHEMBL14040998 | 0.77 | DCLRE1B (0.49) | PTPN1 | |
| SCHEMBL14040913 | 0.77 | ESR2 (0.54) | MAOB | |
| SCHEMBL18210650 | 0.74 | KIF11 (0.60) | PTPN5PTPN1KCNH2KIF11RXRA | |
| SCHEMBL28297682 | 0.74 | PTPN1 (0.58) | PTPN5PTPN1KCNH2KIF11RXRA | |
| SCHEMBL28297513 | 0.74 | PTPN1 (0.58) | PTPN5PTPN1KCNH2KIF11RXRA | |
| SCHEMBL14041077 | 0.73 | HSD17B1 (0.56) | — | |
| SCHEMBL1623873 | 0.73 | KIF11 (0.55) | PTPN5PTPN1KIF11RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373257-B9 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2008-10-15 | — | — | EP | disclosed |