Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 2/20 | 0.41 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | F13A1 | P00488 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.36 |
| ▸ | TGM1 | P22735 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953829 | 0.92 | GSK3B (0.49) | TRPC3TRPC7GRIN2BGSK3BCYP2D6 | |
| SCHEMBL13305198 | 0.84 | GSK3B (0.56) | TRPC3TRPC7GRIN2BGSK3BCYP2D6 | |
| SCHEMBL14043203 | 0.84 | TRPC3 (0.44) | TRPC3TRPC7GRIN2BGSK3BCYP2D6 | |
| SCHEMBL13304833 | 0.82 | CA2 (0.52) | TRPC3TRPC7GRIN2BGSK3BCYP2D6 | |
| SCHEMBL13305170 | 0.80 | TRPC3 (0.43) | TRPC3TRPC7GRIN2BGSK3BCYP2D6 | |
| SCHEMBL13146084 | 0.78 | GSK3B (0.49) | GSK3BCDK2MAPK1KDM4ENPC1 | |
| SCHEMBL13304793 | 0.78 | MAPK1 (0.41) | GRIN2BGSK3BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL13305133 | 0.78 | TRPC3 (0.53) | TRPC3TRPC7GRIN2BCYP2D6CYP2C9 | |
| SCHEMBL12953919 | 0.76 | TRPC3 (0.53) | TRPC3TRPC7GRIN2BCYP2D6CYP2C9 | |
| SCHEMBL12953650 | 0.76 | GSK3B (0.54) | TRPC3TRPC7GRIN2BGSK3BCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |