Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR9 | P51686 | 1/20 | 0.38 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.38 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 2/20 | 0.35 |
| ▸ | CCNC | P24863 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 4/20 | 0.34 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.34 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14139367 | 0.80 | ALDH1A1 (0.34) | CCR9PROKR1CCNCCDK8MAPK1 | |
| SCHEMBL14043920 | 0.78 | HDAC1 (0.44) | CCR9MAPK1 | |
| SCHEMBL3356107 | 0.76 | UHRF1 (0.50) | CCR9SMARCA2SMARCA4PROKR1CCNC | |
| SCHEMBL14044077 | 0.72 | DAO (0.50) | UHRF1 | |
| SCHEMBL829075 | 0.69 | UHRF1 (0.46) | CCR9SMARCA2SMARCA4PROKR1CCNC | |
| SCHEMBL16139761 | 0.68 | KMT2A (0.57) | MAPK1 | |
| Hydrochloric Acid SCHEMBL4416579 | 0.68 | UHRF1 (0.45) | CCR9SMARCA2SMARCA4PROKR1CCNC | |
| SCHEMBL16200404 | 0.68 | POLB (0.43) | CCR9SMARCA2SMARCA4PROKR1 | |
| SCHEMBL31386781 | 0.67 | HCAR2 (0.39) | PDE4D | |
| SCHEMBL14879418 | 0.67 | HCAR2 (0.48) | MAPK1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435830-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |