Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.50 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | ALPG | P10696 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3356107 | 0.79 | UHRF1 (0.50) | LMNAKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL28875184 | 0.77 | HCAR2 (0.72) | DAOHCAR2LMNASMN1; SMN2MEN1 | |
| SCHEMBL14044113 | 0.73 | KDM4E (0.53) | DAOHCAR2LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL14044140 | 0.72 | CCR9 (0.38) | UHRF1 | |
| SCHEMBL14139367 | 0.72 | ALDH1A1 (0.34) | CYP3A4CYP2C9CYP2C19ALDH1A1GAA | |
| SCHEMBL16139761 | 0.71 | KMT2A (0.57) | LMNAKDM4ESMN1; SMN2MEN1KMT2A | |
| SCHEMBL13184263 | 0.71 | BAZ2B (0.47) | KDM4EKMT2AALPLRAB9ANPC1 | |
| SCHEMBL2321608 | 0.71 | DHODH (0.49) | DAOHCAR2MEN1KMT2ARAB9A | |
| SCHEMBL28424649 | 0.71 | DAO (0.49) | DAOHCAR2LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL353289 | 0.70 | KDM4C (0.61) | KDM4EALDH1A1UHRF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435830-B2 | Bicyclic and bridged nitrogen heterocycles | CHEMOCENTRYX, INC. (US) | 2008-10-14 | — | — | US | disclosed |