SCHEMBL14044206

SCHEMBL14044206

BCc1ccc(N2CCC(c3cc(Cl)cc(Cl)c3)(C(F)(F)F)C2)cc1

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.32
MAPT P10636 1/20 0.32
AR P10275 3/20 0.31
OPRL1 P41146 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL540123 0.88 MAPT (0.32) MAPTAROPRL1
SCHEMBL540173 0.84 MAPT (0.40) MAPTAR
SCHEMBL541199 0.81 KCNH2 (0.41) KCNH2AR
SCHEMBL539835 0.81 KCNJ6 (0.33) MAPTAR
SCHEMBL8931774 0.81 MEN1 (0.37) MAPTAR
SCHEMBL540513 0.81 CNR1 (0.34) KCNH2AR
SCHEMBL27964095 0.80 METAP2 (0.33)
SCHEMBL20056502 0.80 HTR1A (0.32)
SCHEMBL539838 0.80 RXRA (0.38) AR
SCHEMBL540579 0.80 AR (0.37) MAPTAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008128711-A1 INSECTICIDAL ARYL PYRROLIDINES BAYER CROPSCIENCE AG (DE) 2008-10-30 WO disclosed