SCHEMBL14044263

SCHEMBL14044263

Cc1cccc(-c2c3ccc(=O)cc-3oc3cc(O)ccc23)c1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.76
KMT2A Q03164 4/20 0.76
USP2 O75604 3/20 0.76
POLB P06746 2/20 0.76
ATM Q13315 1/20 0.76
PLEC Q15149 1/20 0.76
ALPL P05186 1/20 0.60
ALPI P09923 1/20 0.60
ALPG P10696 1/20 0.60
CA9 Q16790 5/20 0.59
CA12 O43570 4/20 0.59
L3MBTL1 Q9Y468 1/20 0.54
ALDH1A1 P00352 2/20 0.48
HPGD P15428 2/20 0.48
TNKS O95271 1/20 0.48
CYP3A4 P08684 1/20 0.48
PARP1 P09874 1/20 0.48
CYP2C9 P11712 1/20 0.48
TNKS2 Q9H2K2 1/20 0.48
QPCT Q16769 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14044262 0.86 USP2 (0.77) MEN1KMT2AUSP2POLBATM
SCHEMBL940682 0.86 MEN1 (1.00) MEN1KMT2AUSP2POLBATM
SCHEMBL14210376 0.85 MEN1 (0.71) MEN1KMT2AUSP2POLBATM
SCHEMBL10082267 0.84 MEN1 (0.72) MEN1KMT2AUSP2POLBATM
SCHEMBL13320830 0.84 USP2 (0.76) MEN1KMT2AUSP2POLBATM
SCHEMBL29974216 0.84 USP2 (0.76) MEN1KMT2AUSP2POLBATM
SCHEMBL10030600 0.83 USP2 (0.64) MEN1KMT2AUSP2POLBATM
SCHEMBL12909281 0.82 USP2 (0.62) MEN1KMT2AUSP2POLBATM
SCHEMBL9910747 0.81 MEN1 (0.72) MEN1KMT2AUSP2POLBATM
SCHEMBL12909301 0.81 USP2 (0.68) MEN1KMT2AUSP2POLBATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170082642-A1 FLUORESCENT CELL MARKERS KODE BIOTECH LTD (NZ) 2017-03-23 US disclosed
US-7439035-B1 Method of identifying or characterizing a compound that modulates ribonuclease H activity MCGILL UNIVERSITY (CA) 2008-10-21 US disclosed
US-7186520-B1 Substrate for assaying ribonuclease H activity MCGILL UNIVERSITY (CA) 2007-03-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170082642-A1 FLUORESCENT CELL MARKERS PTDSS2, SPTLC2, CD69 MEN1 1577/4885KMT2A 3441/4885USP2 1329/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.