Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | CASP1 | P29466 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7273128 | 0.94 | EGFR (0.55) | EGFRPIK3CDPIK3CANPC1POLB | |
| SCHEMBL6647315 | 0.83 | NPC1 (0.62) | NPC1POLBRAB9APDGFRBPDGFRA | |
| SCHEMBL31124778 | 0.82 | EGFR (0.65) | EGFRPIK3CDPIK3CAALDH1A1KDM4E | |
| SCHEMBL4985353 | 0.82 | EGFR (0.65) | EGFRPIK3CDPIK3CAALDH1A1KDM4E | |
| Quinoline SCHEMBL156755 | 0.78 | EGFR (0.80) | EGFRPIK3CDPIK3CANPC1POLB | |
| SCHEMBL4523676 | 0.78 | EGFR (0.47) | EGFRPIK3CDPIK3CA | |
| SCHEMBL7235686 | 0.77 | CLK1 (0.54) | NPC1POLBRAB9APDGFRBPDGFRA | |
| Naphthalene SCHEMBL7849032 | 0.77 | EGFR (0.77) | EGFRPIK3CDPIK3CANPC1POLB | |
| SCHEMBL4750534 | 0.77 | CLK1 (0.54) | NPC1POLBRAB9APDGFRBPDGFRA | |
| Quinoline SCHEMBL27927382 | 0.77 | EGFR (0.77) | EGFRPIK3CDPIK3CANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130515-A1 | ANTI-CANCER AGENTS, COMPOSITIONS AND METHODS OF TREATING CANCERS | ACB, LLC (US) | 2008-10-30 | — | — | WO | disclosed |