Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14045513 | 0.78 | LMNA (0.45) | LMNATHRBCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL2832753 | 0.76 | LMNA (0.67) | LMNATHRBCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL12510334 | 0.68 | MAPK1 (0.38) | LMNATHRBCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL15607850 | 0.67 | ALDH1A1 (0.54) | KDM4EL3MBTL1 | |
| SCHEMBL14023815 | 0.67 | LMNA (0.64) | LMNATHRBCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL3915318 | 0.64 | LMNA (0.68) | LMNATHRBCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL15545360 | 0.64 | CYP3A4 (0.39) | LMNATHRBCYP2C19CYP3A4CYP2D6 | |
| SCHEMBL12231940 | 0.64 | — | — | |
| SCHEMBL14547199 | 0.63 | CYP3A4 (0.61) | LMNACYP3A4CYP2D6OPRK1POLB | |
| SCHEMBL15607935 | 0.62 | LMNA (0.64) | LMNATHRBCYP2C19CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432295-B2 | Preparation of compounds useful for the detection of hypoxia | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-10-07 | — | — | US | disclosed |