Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14499615 | 0.75 | LMNA (0.78) | LMNATHRBCYP2C19FPR2GRIN2B | |
| SCHEMBL12231940 | 0.72 | — | — | |
| SCHEMBL12510334 | 0.70 | MAPK1 (0.38) | LMNATHRBCYP2C19KDM4EALDH1A1 | |
| SCHEMBL22057306 | 0.67 | — | — | |
| SCHEMBL22057304 | 0.66 | LOXL2 (0.30) | — | |
| SCHEMBL22057392 | 0.66 | — | — | |
| SCHEMBL14547199 | 0.65 | CYP3A4 (0.61) | LMNAGRIN2BHTTALDH1A1POLB | |
| SCHEMBL22057394 | 0.65 | ALDH1A1 (0.33) | ALDH1A1POLB | |
| SCHEMBL8131223 | 0.65 | ALDH1A1 (0.54) | CYP2C19KDM4EHTTALDH1A1POLB | |
| SCHEMBL5982226 | 0.65 | LMNA (0.43) | LMNATHRBGRIN2BKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432295-B2 | Preparation of compounds useful for the detection of hypoxia | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-10-07 | — | — | US | disclosed |