Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13249878 | 0.93 | KMT2A (0.49) | P2RX7KMT2AMAPTNPSR1MTHFD2 | |
| SCHEMBL13249862 | 0.87 | P2RX7 (0.52) | P2RX7ALDH1A1HPGDHTT | |
| SCHEMBL13249831 | 0.85 | MTHFD2 (0.46) | P2RX7MTHFD2 | |
| SCHEMBL13249869 | 0.85 | HTT (0.43) | P2RX7MAPTNPSR1KDM4EALDH1A1 | |
| SCHEMBL13249882 | 0.84 | P2RX7 (0.52) | P2RX7 | |
| SCHEMBL13249829 | 0.83 | KMT2A (0.44) | P2RX7KMT2AMAPTALDH1A1CYP3A4 | |
| SCHEMBL13249874 | 0.81 | MTHFD2 (0.43) | P2RX7KMT2AMTHFD2ALDH1A1HPGD | |
| SCHEMBL13249822 | 0.81 | P2RX7 (0.47) | P2RX7NPSR1MTHFD2CYP3A4CYP2C9 | |
| SCHEMBL13249853 | 0.81 | L3MBTL1 (0.43) | P2RX7MTHFD2ALDH1A1CYP3A4 | |
| SCHEMBL13249858 | 0.81 | PRLHR (0.45) | P2RX7MTHFD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130581-A1 | PYRIMIDINONE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |