Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 13/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5048799 | 0.81 | CRHR1 (0.35) | CRHR1 | |
| SCHEMBL5043932 | 0.79 | CRHR1 (0.31) | CRHR1 | |
| SCHEMBL6022724 | 0.77 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL5043125 | 0.76 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL5043423 | 0.76 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL14031202 | 0.76 | PKM (0.36) | CRHR1 | |
| SCHEMBL5778487 | 0.75 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL6022722 | 0.74 | CRHR1 (0.34) | CRHR1RXRARXRBRXRG | |
| SCHEMBL5039155 | 0.74 | MAPT (0.34) | CRHR1 | |
| SCHEMBL5776900 | 0.74 | MEN1 (0.32) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432283-B2 | Heterocyclic GABAA subtype selective receptor modulators | ROCHE PALO ALTO LLC (US) | 2008-10-07 | — | — | US | disclosed |