Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 12/20 | 0.57 |
| ▸ | NOS1 | P29475 | 12/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | NOS2 | P35228 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14049832 | 0.87 | NOS3 (0.54) | NOS3NOS1KCNH2NOS2ALDH1A1 | |
| SCHEMBL2675137 | 0.85 | NOS3 (0.57) | NOS3NOS1KCNH2NOS2ALDH1A1 | |
| SCHEMBL2675751 | 0.85 | NOS3 (0.54) | NOS3NOS1KCNH2NOS2ALDH1A1 | |
| SCHEMBL2675266 | 0.78 | NOS3 (0.50) | NOS3NOS1KCNH2NOS2ALDH1A1 | |
| SCHEMBL14049727 | 0.76 | MEN1 (0.42) | NOS3NOS1ALDH1A1MAPTKDM4E | |
| SCHEMBL2676597 | 0.74 | NOS3 (0.63) | NOS3NOS1KCNH2NOS2LMNA | |
| SCHEMBL2676601 | 0.74 | NOS3 (0.98) | NOS3NOS1KCNH2NOS2 | |
| SCHEMBL2676126 | 0.73 | NOS3 (0.44) | NOS3NOS1KCNH2ALDH1A1MAPT | |
| SCHEMBL25818515 | 0.71 | ALDH1A1 (0.54) | NOS3NOS1KCNH2NOS2ALDH1A1 | |
| SCHEMBL2676188 | 0.71 | NOS3 (0.52) | NOS3NOS1KCNH2NOS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008116308-A1 | QUINOLONE AND TETRAHYDROQUINOLINE AND RELATED COMPOUNDS HAVING NOS INHIBITORY ACTIVITY | NEURAXON, INC. (CA) | 2008-10-02 | — | — | WO | disclosed |